Background: Dyslipidemia is one of the important causes of cardiovascular disease related mortality and morbidity. Recently it has become a significant issue in public health problem of developing countries. The purpose of the study was to find a suitable solution for reducing blood lipid in dyslipidemic patients by conducting a research on the effect of cinnamon in hypercholesterolemic rats.Objective: To study the lipid lowering effect of Cinnamomum cassia on experimentally induced hypercholesterolemic rats.Materials and Methods: This study was done on 30 male Long Evans rats weighing about 200--210 gram. For convenience, the study was divided into two experiments --- Experiment I and Experiment II. In experiment I, 12 animals were divided into two groups. One was Group A (n = 6, control group) fed on laboratory diet and the other was Group B (n = 6) fed on laboratory diet and cinnamon for 35 days. In experiment II, the remaining 18 rats were fed fatty mixture diet containing 1% cholesterol and 0.25% cholic acid. The hypercholesterolemic rats were then divided into 3 groups, Group C, D, and E (n=6 in each group). Group D and Group E were additionally fed on cinnamon powder and tablet atorvastatin for 35 days respectively. Serum TC, TG, LDL-C and HDL-C were measured after 35 days.Results: Fatty mixture diet increased TG, TC and LDL-C significantly. Cinnamon treated fatty mixture diet group showed that Cinnamomum cassia decreased plasma TC, TG and LDL-C. Atorvastatin therapy decreased TC, TG and LDL-C levels significantly compared with the lowering effect of cinnamon.Conclusion: The results of this experimental study indicate that Cinnamomum cassia can act as a hypocholesterolemic agent and thereby can improve cardiovascular functions

Background: Skin problems are one of the most common health problems seen in the developing countries.

Objective : To determine the association of blood pressure and other biochemical parameters with type 2 DM subjects. Methodology :This was an observational study with case control design was conducted in the Biomedical Research Group, Research Division, Bangladesh Institute of Research and Rehabilitation in Diabetes ,Endocrine Metabolic Disorders (BIRDEM), Dhaka Bangladesh, during the period of July 2008 to June 2009. A total of 153 subjects were included in study of which 63 belonged to T2 Diabetes Mellitus group and 90 were healthy Controls. Insulin glucose ratio were assayed in patients and controls and identified the association, using standardized assay methods. We also assessed the type -2 diabetic patients who had significantly raised Fasting blood sugar, insulin HOMA-B %= B cell function assessed by homeostasis model assessment to compared with the healthy controls. Correlation analysis of HOMA-B % with biochemical parameters, blood pressure, fasting and post prandial glucose also analysed.Results : Age of Control and type 2 DM subjects ( Mean±SD),P-value] were (46 ± 8.31) and (47 ±7.58), (P=0.326) respectively and BMI, among subject and control (kg/m 2) , (Mean ± SD), (24 ± 3.96, 25 ± 2.72 p=0.754). WHR [cm, (Mean±SD), p=<0.001], showed significant difference between T2 DM and healthy subjects. The median (range) of the glucose and insulin ratio of the study group, there was significant difference between Control vs. T2DM (p<0.001). Systolic blood pressure[S-BP, mean±SD] & Diastolic blood pressure [D-BP, mean±SD] were significant in T2DM as compared to control subjects {( p= 0.008) ( p= 0.003)} respectively ; Fasting plasma glucose levels [mmol/l, (Mean± SD)] , post prandial plasma glucose level [mmol/l, (Mean± SD)]and the HOMA%B level median (range) among subject and control of the study group [(8.27±2.19) , (11.79 ± 2.69), {71 ( 4.90 -391.30)}] were a significant difference in between Control vs type2 DM {(p <0.001), (p <0.001)and. (p <0.001)} respectively. Conclusion :In this study, boty systolic and diastolic blood pressure, blood glucose level and insulin status and WHR were found the significant parameters for maintaining type to DM under control condition. Development of hypertension cardio vascular disease and other complication can be prevented on keeping these parameters in normal level.

Contrext: The pituitary gland produces several hormones that regulate growth, metabolism and reproduction. Deviations from the normal functions of the gland certainly derange the harmony of life.