Central giant cell granuloma (CGCG) is an uncommon, benign, intraosseous bony lesion of the mandible and maxilla which is variably aggressive in nature. The incidence of an aggressive and recurrence nature is greatest in a female with a ratio of 2:1. Based on the clinical and radiographic features, Central giant cell granuloma can be classified as aggressive and non-aggressive lesions. Here we report a case of central giant cell granuloma in the posterior mandibular molar region which was aggressive in nature. The clinically and radiographically swelling was evaluated with displaced tooth, pain, cortical expansion, and root resorption. The treatment varies according to the nature of the lesion, this case was treated by conservative excision with continuity of the mandible. Key words: Aggressive, central giant cell granuloma, osteolytic lesion.

Odontogenic myxoma is a benign locally aggressive odontogenic tumor that arises from the mesenchymal portion of the tooth germ. They occur most frequently in the second or third decade of life and rarely occur before the age of 10 and after the age of 50. These are slow-growing tumors, but they may be locally aggressive, especially in the maxilla. Here we report the case of odontogenic myxoma in a 25-year-old male patient in the mandibular anterior region, which is usually seen in the posterior aspect of the mandible.