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In conclusion, persistence with endocrine treatment in woman with hormone-receptor-positive breast cancer is low, especially in later stage disease, and needs to be significantly increased to improve outcome in clinical practice. Further research is required to understand this complex, but important aspect.

Background: Cardiovascular diseases remain the number one cause of death worldwide, and many survivors suffer lasting disabilities. Occupational therapy can help such patients regain as much function as possible. However, little is known about the factors influencing referrals to occupational therapy after stroke or myocardial infarction (MI). Method: Data from the IMS Disease Analyzer ® database were observed for a three-year period. The study population included 7,440 patients who were examined by a cardiologist due to stroke or MI. In addition to baseline characteristics, the presence of certain cardiovascular risk factors or comorbidities was recorded. Cox regression analyses were performed and the Charlson Comorbidity Index (CCI) was utilized. Results: Occupational therapy was received by 1,779 patients; 88.5% had suffered an MI and 11.5% a stroke. In the group without referral (n = 5,661), 60.7% had experienced an MI and 39.3% a stroke. No significant gender-related differences were observed. Younger age, an MI diagnosis, and the presence of hypertension positively influenced referral rate and time, while risk factors, such as adiposity, delayed therapy. The CCI was higher in the group with occupational therapy. Conclusion: The chance of being offered occupational therapy increased with younger age, history of MI, and the presence of hypertension. Future studies should also consider severity of ischemic lesion to account for the degree of remaining impairment.

A505anxiety disorders in 65%, ADHD in 61%, impaired social behaviour in 85%, depression in 23%, and seizures in 4%. Medical therapy for comorbidities was often prescribed. ConClusions: The registry is expected to provide much-needed data on the characteristics and management situation of FXS patients in Germany, to allow comparisons with other countries, and to enable gap analyses based on current guidelines for management of these patients. ClinTrials. gov identifier is NCT01711606.objeCtives: To conduct a systematic review of randomised controlled trials comparing effectiveness of GnRHa in the treatment of endometriosis in order to assess the feasibility of conducting a meta-analysis and indirect treatment comparison. Methods: Inclusion criteria were all published randomized controlled trials comparing GnRHa versus any other pharmacological treatment or placebo in the treatment of laparoscopically confirmed moderate to severe endometriosis. Electronic databases were searched up to February 2014 (Embase, Medline, Cochrane, Clintrials. gov and clinical conferences). Search results were screened, eligible studies were assessed for risk of bias and data extracted. Studies were evaluated for the feasibility of inclusion into a network meta-analysis. Results: A total of 1,670 titles and abstracts were screened. Sixty-nine papers relating to 62 studies were identified as eligible for inclusion. Fourteen of the 62 were excluded due to high risk of bias, a further 21 did not present sufficient data. The remaining 27 studies showed clinical heterogeneity in the measurement of disease severity and efficacy outcomes and quality of reporting. Efficacy outcomes were measured using various methods and at different time points (3, 6 to 12 months). All but one measured pain, 12 using modified versions of the Biberoglu and Behrman (B&B), 7 using a similar method and 4 used a visual analogue scale. Quality of life was measured in 7 studies, most commonly by a generic HRQoL instrument, the SF-36. Adverse event recording varied. ConClusions: A core set of studies were identified that could be incorporated into a quantitative analysis assessing effectiveness of GnRHa for treatment of moderate to severe endometriosis over 6 months. A network meta-analysis would potentially be feasible using more commonly reported pain outcomes, (modified) B&B; HRQoL and reported adverse events.