<p class="abstract"><strong>Background:</strong> Acute viral bronchiolitis is the most common infection of the lower respiratory tract in infants under 2 years and is one of the reasons for their admission all around the world. The aim of this study was comparing the effect of zinc gluconate and placebo in the treatment of tachypnea, dyspnea and fever in children aged 2 to 23 months with acute bronchiolitis.</p><p class="abstract"><strong>Methods:</strong> This randomized clinical trial study has been done on 100 infants aged 2 to 32 months with the diagnosis of bronchiolitis who divided in two groups. 50 patients received zinc gluconate and 50 patients received placebo. The symptoms and sign of the disease at baseline and then at 24, 72, and 7 days after starting treatment and duration of hospitalization were compared between the two groups.</p><p class="abstract"><strong>Results:</strong> The treatment and placebo groups were similar in respect to mean age and gender distribution. Two groups were similar in terms of clinical symptoms and signs at the time of admission. Bronchiolitis recovery was better in the treatment group than in the placebo group. This positive effect was statistically significant for vising (p=0.023) and rhinorrhea (p=0.027) at 72 hours after starting treatment. The mean duration of hospitalization was significantly less in the treatment group than in the placebo group (4.14±1.21 versus 4.64±1.2 days; p=0.016).</p><p class="abstract"><strong>Conclusions: </strong>Results showed that the use of zinc gluconate as a zinc supplement in infants with acute bronchiolitis could improve their clinical symptoms and signs and decrease the duration of hospitalization.</p>

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Background: Neonatal seizures are the primary and most important signs of neurologic function disorders that often lead to serious complications. However, this disorder is predictable and manageable with suitable diagnostic and therapeutic methods. The aim of this study was to investigate the frequency, causes, and findings of brain CT scans of neonatal seizure.Methods: This descriptive cross-sectional study has been done on 70 neonates with seizures who hospitalized in Ardabil city hospital during 2016-2017. CT scans were done for all patients. Necessary information for each patient was recorded in a checklist including demographic data, history of diabetes mellitus, hypertension, and maternal endocrine disorders, and history of resuscitation and clinical data including type of seizure and its duration, Cause of seizure and CT scan findings (cerebral hemorrhage, local ischemic lesions, hypoxemic-ischemic encephalopathy, and anatomical cerebral malformations).Results: The mean age of neonates was 12.41±9.33 days. Of them, 61.4% were boys, 3.24% LBW and 40% were preterm at birth time. Of all neonates, 21.4% had history of seizure in their relative degree family members. Fever was the most common symptom accompanying seizures (40%). The most common form was tonic seizure (n=30, 42.9%) and its duration time was 4.99 minute.  A total of 41.4% of neonates (29 cases) had abnormal CT scan reports. Hypoxic-ischemic encephalopathy (47%) was the most common findings in the CT scans of neonates with seizures.Conclusions: Results showed that, a considerable number of neonates had abnormal CT findings and the most common abnormal form was hypoxemic-ischemic encephalopathy.

<p class="abstract"><strong>Background:</strong> Neonatal jaundice is one of the most common problems in the neonatal period. Eosinophilia is common in preterm and term newborns, and it is considered when the absolute count of eosinophil is ≥500 cell/mm³. It is thought that there was some relationship between hyperbilirubinemia and increasing of blood eosinophil count in newborns hospitalized by jaundice. The aim of this study was to determine the prognostic value of peripheral blood eosinophil count on first day of infancy in the incidence of neonatal hyperbilirubinemia.</p><p class="abstract"><strong>Methods:</strong> 150 newborns with gestational ages of 35-40 weeks, born in Ardabil city hospital, were engaged in this study. After obtaining the parents' consent, getting patients biography and their physical examination, we got a blood sample from umbilical cord of newborns to measure differential count of white blood cells. The neonates were observed up to 28 day followed. Then, second blood test conducted for the purpose of measuring serum level of bilirubin. Data were analyzed by statistical methods in SPSS version 19.  </p><p class="abstract"><strong>Results:</strong> Various group of age, sex, blood type and gestational age showed no significant difference in their eosinophil rate. Total serum bilirubin doesn't had a significant relationship with gestational age, sex, type of delivery and major or minor blood groups of neonates.</p><p class="abstract"><strong>Conclusions:</strong> Results showed that there was no significant relationship between the amount of eosinophil in newborn umbilical cord and total serum bilirubin. So, we could say that newborns eosinophil count isn’t a good criteria for predicating the appearance of neonate hyperbilirubinemia.</p>

Background: Estimation of bronchiolitis severity in infants is still an important issue and there are no standard methods to help physicians for better evaluation and management of clinical status of these patients. The aim of this study was to investigate the role LDH concentration in NW as a biomarker in evaluation the outcome of patients suffering bronchiolitis in Bu Ali Hospital, Ardabil.Methods: 100 children with bronchiolitis aged below 2 years entered the study. Nasal wash sample was extracted from all patients using 2 ml of normal saline. Samples were sent to laboratory to measure LDH level. Data were analyzed by statistical methods in SPSS.16.Results: The mean age of patients was 6.9±3.7 months and 57% of them were male. 42% of patients had mild bronchiolitis and 58% of them suffered from severe bronchiolitis. The LDH level of nasal wash fluid was neither related with gender nor with age. But it was significantly lower in patients who required oxygen therapy and had fever compared with those who did not require oxygen therapy and without fever. Moreover, LDH level showed a significant negative association with hospital stay (r= -0.570, p<0.001) and bronchiolitis severity (r= -0.440, p<0.001) in a way that its concentration was significantly lower in patients with hospital stay longer than 24 hours compared with hospital stay shorter than 24 hours, and in patients with severe bronchiolitis compared with mild bronchiolitis.Conclusions: According to results of this study, LDH measurement in nasal wash fluid can be used as a biochemical marker to evaluate clinical outcomes of bronchiolitis in children younger than 24 months.