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This research. Included the preparation. and characterization some novel. Six and seven membered Heterocyclic. Compounds ( oxazepine , thiazine , quinazoline ) The first step in clode react 2-amino-6- methoxybenzothiazole with 4- amino acetophenone to get Schiff base derivative (1). The second step react (1) with 4 -hydroxy acetophenone to get schiff base derivative (2) the last step involve react (2) with ( Phthalic , Maleic , Succinic) anhydride to .get oxazepine derivatives (3,4and 5) also react (2) with(2-amino benzoic acid) and (2-mercaptobenzoic acid ) to get quinazoline (6)and thiazine (7) derivatives respectively .the physical; properties of the prepared; These Compounds. Were Identification (FT-IR) ,(1H-NMR) and (13C-NMR) by spectroscopy thene study their biological effect on two types of bacteria Staphylococcus aureuses (Gram positive) and Escherichia coli (Gram Negative)