Stress in college students have negative impacts to their lectures and performance. The aim was to determine comparison of stress level in medical college of 2018 with 2015 in medical faculty of Baiturrahmah University. This  research  was  cross  sectional study, observational unpaired  categorical  comparative  analytics. The participants were 80 peoples. Stress was assessed by using Perceived Stress Scale (PSS-10). Data obtained was tabulated and analyzed using chi-square. The result, The medical college of 2015 had moderate stress (87.5%), the medical college of 2018 had moderate stress (60%) and there was a significant difference in stress level between  the  two  groups,  the medical  college of 2015 was  higher  than  the  2018,  p  =  0.020  (p  <0.05). The conclusion was the medical college of 2015 and the 2018 had moderate stress and stress in medical college of 2015 was higher than the 2018.