ABSTRAK Telah dilakukan penelitian mengenai formulasi patch transdermal alkaloid nikotin daun tembakau (Nicotiana tobacum L) sebagai terapi ketergantungan rokok dengan variasi polimer dan asam oleat sebagai peningkat penetrasi. Tujuan penelitian  ini adalah untuk memformulasikan  patch transdermal alkaloid nikotin daun tembakau yang stabil dan untuk melihat pengaruh penambahan eti cellulose, PVP dan asam oleat terhadap pelepasan nikotin secara in vitro. Formulasi patch transdermal terdiri dari alkaloid nikotin daun tembakau, PVP, etil cellulosa, PVP,PEG 400, propilenglikol dan asam oleat. Pada penelitian ini dibuat 3 formula dengan varian konsentrasi PVP:EC yaitu F1= 1:1  F2= 1:2 dan F3= 1:3 dan variasi peningkat penetrasi berupa asam oleat yaitu F1:0,10, F2: 0,15, dan F3 : 0,20. Evaluasi terhadap sediaan patch transdermal meliputi organoleptik, uji bobot matrik, uji ketebalan matrik, persentase susut pengeringan, moisture uptake, uji ketahanan lipatan matrik, uji iritasi kulit, uji pH permukaan matrik patch, persentase pemanjangan, uji frezee and thaw, uji kandungan nikotin, dan  uji pelepasan nikotin (sel difusi), Berdasarkan uji stabilitas fisik semua formula patch transdermal relatif stabildan kinetika pelepasan patch transdermal mengikuti orde satu dan hasil analisis statistik dengan menggunakan Analisis Varian (ANOVA) menunjukan p=0,000 menunjukkan adanya perbedaan yang signifikan pada F1,F2 dan F3, dan berdasarkan uji Korsmayer peppas mengikuti hukum non fick

Research on the tobacco leaves  nicotine alkaloid (Nicotiana tobacum L) transdermal patch formulation has been carried out as a cigarette dependence therapy with variations in polymers and oleic acid as a penetration enhancer. The purpose of this study is to formulate a stable transdermal patch of nicotine alkaloid tobacco leaf and to see the effect of adding cellulose, PVP and oleic acid to the release of nicotine in vitro. Transdermal patch formulation consists of nicotine alkaloid tobacco leaf, PVP, ethyl cellulose, PVP, PEG 400, propylenglycol and oleic acid. In this study, 3 formulas were made with concentration variants of PVP: EC namely F1 = 1: 1, F2 = 1: 2, and F3 = 1: 3, where the variations in penetration enhancements in the form of oleic acid were F1: 0.10, F2: 0.15, and F3: 0.20. Evaluation of transdermal patch preparations includes organoleptic, matrix weight test, matrix thickness test, drying shrinkage percentage, moisture uptake, matrix fold resistance test, skin irritation test, patch matrix surface pH test, elongation percentage, frezee and thaw test, nicotine content test, and nicotine release (diffusion cell) test, based on physical stability test of all relatively stable transdermal patch formulas and kinetics of transdermal patch release kinetics following first order and the results of statistical analysis using Variant Analysis (ANOVA) showed differences in F1, F2 and F3, and based on the Korsmayer Peppas test following the non-fick law