There is controversy about the relationship between ACE I/D polymorphism and health. Seventy-four healthy adults (n = 28 women; 22.5 ± 4.2 years) participated in this cross-sectional study aimed at determining the influence of ACE I/D polymorphism, ascertained by polymerase chain reaction, on cardiometabolic risk (i.e., waist circumference, body fat, blood pressure (BP), glucose, triglycerides, and inflammatory markers), maximal fat oxidation (MFO), cardiorespiratory fitness (maximal oxygen uptake), physical activity and diet. Our results showed differences by ACE I/D polymorphism in systolic BP (DD: 116.4 ± 11.8 mmHg; ID: 116.7 ± 6.3 mmHg; II: 109.4 ± 12.3 mmHg, p = 0.035) and body fat (DD: 27.3 ± 10.8%; ID: 22.6 ± 9.7%; II: 19.3 ± 7.1%, p = 0.030). Interestingly, a genotype*sex interaction in relativized MFO by lean mass (p = 0.048) was found. The DD polymorphism had higher MFO values than ID/II polymorphisms in men (8.4 ± 3.0 vs. 6.5 ± 2.9 mg/kg/min), while the ID/II polymorphisms showed higher R-MFO values than DD polymorphism in women (6.6 ± 2.3 vs. 7.6 ± 2.6 mg/kg/min). In conclusion, ACE I/D polymorphism is apparently associated with adiposity and BP, where a protective effect can be attributed to the II genotype, but not with cardiorespiratory fitness, diet and physical activity. Moreover, our study highlighted that there is a sexual dimorphism in the influence of ACE I/D gene polymorphism on MFO.

It is unknown whether resting fat oxidation (RFO), maximal fat oxidation (MFO) and FatMax (intensity at which MFO is reached) are related to cardiometabolic risk (CMR). Thus the aim of this study was to examine the association of RFO, MFO and FatMax with CMR. 81 healthy adults (n = 31 women; 22.72 ± 4.40 years) participated in this cross-sectional study. Glucose and triglycerides were analysed in plasma. Body composition, anthropometry, physical activity, blood pressure (BP) and heart rate measurements were taken. RFO and MFO were determined through indirect calorimetry. Maximal oxygen uptake (VO 2 max) test was performed until exhaustion after MFO test. The CMR cluster was created from individual CMR factors: waist circumference, body fat percentage, systolic BP, diastolic BP, blood glucose and plasma triglycerides. Groups of high and low MFO and VO 2 max were created. RFO was not associated with CMR (p < 0.05). FatMax, MFO and VO 2 max were associated with individual CMR factors as waist circumference (R 2 = 0.144; R 2 = 0.241; R 2 = 0.285; p = 0.001; respectively) and plasma triglycerides (R 2 = 0.111; p = 0.004 and R 2 = 0.130; p = 0.002 and R 2 = 0.093; p = 0.008; respectively) and clustered CMR factors (R 2 = 0.105; p = 0.008 and R 2 = 0.162; p = 0.001 and R 2 = 0.239; p = 0.001; respectively). VO 2 max was also associated with body fat percentage (R 2 = 0.105; p = 0.003) and diastolic BP (R 2 = 0.083; p = 0.01), even adjusting for sex or age (p < 0.05). Groups with high level of MFO or VO 2 max obtained lower CMR (p = 0.001), even adjusting for sex or age (p < 0.01). FatMax, MFO and, especially, VO 2 max are associated with CMR, regardless of age and sex. However, RFO is not associated with CMR.

The present work aimed to examine the association between physical activity (PA) and sedentary behaviour with maximal fat oxidation (MFO) in young individuals. A total of 77 active adults (30 women; 22.8 ± 4.5 years) were included in this cross-sectional study in which PA and sedentary behaviour were measured using accelerometers for 7 consecutive days. PA was classified into different intensities (i.e. light, moderate, vigorous, and moderate-to-vigorous) and sedentary behaviour into sedentary time (i.e. time, number of bouts, and length of bouts) and sedentary breaks (i.e. time, number of breaks, and length of breaks). MFO was determined using a graded cycloergometer test through indirect calorimetry and relativized to lean mass (MFO LM ) and lean leg mass (MFO LL ). Positive associations were found for light and vigorous PA in relation with MFO, MFO LM and MFO LL , independently of cofounders (P ≤ 0.01). Moreover, a negative association was found between MFO and MFO LM and the length of sedentary bouts which was accentuated after adjusting by cardiorespiratory fitness (P ≤ 0.05). These results suggest that light and vigorous PA and sedentary behaviour are related to MFO during exercise. Despite this, further interventional studies are needed to clarify if increments of light and vigorous PA could enhance MFO in different populations.

ResumenIntroducción: El ejercicio físico es imprescindible para las personas con DMT2, aunque, con frecuencia se presentan problemas para practicarlo, siendo el más frecuente la falta de tiempo. No obstante, el auge de métodos como el HIIT aporta una solución a estas barreras, ya que permiten mejorar la salud con unos pocos minutos de ejercicio diarios. Objetivo: Realizar una revisión narrativa sobre los efectos del HIIT en diferentes parámetros de salud en personas con DMT2. Metodología: Tras la búsqueda en bases de datos (PubMed, SPORTDiscus y Medline) se obtiene un total de 52 artículos. Teniendo en cuenta los criterios de inclusión-exclusión, se incluyen 16 artículos. Todos los estudios incluidos son experimentales (ensayos clínicos) publicados en los últimos 10 años. Se excluyen los artículos a los que no se tiene acceso, las revisiones, los estudios cuya intervención sea similar pero no igual al HIIT y aquellos relacionados con genética. Resultados: De total de estudios incluidos (16), hay 14 que afirman que el HIIT mejora la salud de sujetos con DMT2. Se observan mejoras significativas en: perfil lipídico, control glucémico, resistencia a la insulina, HbA1c, tensión arterial, composición corporal, función endotelial y condición física. Hay 2 estudios en los que no se observa ninguna mejora. Conclusiones: El HIIT tiene efectos positivos en la salud de las personas con DMT2, ya que mejora la condición física, la salud cardio-metabólica, la composición corporal y la calidad de vida. El HIIT puede representar una buena estrategia para mejorar la salud en DMT2. Son necesarios más estudios.AbstractIntroduction: Physical exercise is essential for people with T2DM, although there are often problems to practice it, the most frequent being the lack of time. However, the rise of methods such as HIIT provides a solution to these barriers, since they allow improving health with a few minutes of exercise per day. Objective: To carry out a narrative review about the effects of HIIT on different health parameters in people with T2DM. Methodology: After the search in databases (PubMed, SPORTDiscus and Medline) 52 articles were obtained. Taking into account the inclusion-exclusion criteria, 16 articles were included. All included studies are experimental (clinical trials) published in the last 10 years. Excluded are articles that cannot be accessed, reviews, studies whose intervention is similar but not equal to HIIT and those related to genetics. Results: Of the total number of included studies (16), there are 14 that affirm that HIIT improves the health of subjects with T2DM. Significant improvements were observed in: lipid profile, glycemic control, insulin resistance, HbA1c, blood pressure, body composition, endothelial function and physical fitness. There are 2 studies in which no improvement is observed. Conclusions: HIIT has positive effects on the health of people with T2DM, since it improves physical fitness, cardio-metabolic health, body composition and quality of life. HIIT may represent a good strategy to improve health in DMT2. More studies are nedeed.