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femoral cartilage (p ¼ 0.977). Additionally, a negative correlation of GagCEST with KL grade was observed (r¼ -0.404, p¼0.01). The results show that optimized gagCEST methods at 3T were able to detect a statistically significant reduction in gagCEST asymmetry in osteoarthritic subjects, known to have cartilage degeneration and lower biochemical GAG composition, compared to healthy controls. Further analysis showed a significant difference in gagCEST asymmetry between the healthy and OA KL-2 and KL-3 subjects. This decrease can Abstracts / Osteoarthritis and Cartilage 27 (2019) S92eS516 S356