Do immune cells lead the way in subchondral bone disturbance in osteoarthritis?

Weber, Adrian; Chan, Pok Man Boris; Wen, Chunyi

doi:10.1016/j.pbiomolbio.2017.12.004

Cited by 53 publications

(55 citation statements)

References 151 publications

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“…As previously discussed, bone homeostasis is controlled by a tightly regulated balance between bone deposition and bone resorption [ 6 ]. However, this balance can be upset in situations of infection [ 33 ], chronic inflammation [ 34 , 35 ], or cancer [ 6 ]. In particular, osteoblast activity has been shown to be dysregulated in pathological conditions of bone infection such as osteomyelitis.…”

Section: Osteoblasts In the Bone Microenvironment As Contributors mentioning

confidence: 99%

Cancer Metastases to Bone: Concepts, Mechanisms, and Interactions with Bone Osteoblasts

Shupp

Kolb

Mukhopadhyay

et al. 2018

Cancers

114

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The skeleton is a unique structure capable of providing support for the body. Bone resorption and deposition are controlled in a tightly regulated balance between osteoblasts and osteoclasts with no net bone gain or loss. However, under conditions of disease, the balance between bone resorption and deposition is upset. Osteoblasts play an important role in bone homeostasis by depositing new bone osteoid into resorption pits. It is becoming increasingly evident that osteoblasts additionally play key roles in cancer cell dissemination to bone and subsequent metastasis. Our laboratory has evidence that when osteoblasts come into contact with disseminated breast cancer cells, the osteoblasts produce factors that initially reduce breast cancer cell proliferation, yet promote cancer cell survival in bone. Other laboratories have demonstrated that osteoblasts both directly and indirectly contribute to dormant cancer cell reactivation in bone. Moreover, we have demonstrated that osteoblasts undergo an inflammatory stress response in late stages of breast cancer, and produce inflammatory cytokines that are maintenance and survival factors for breast cancer cells and osteoclasts. Advances in understanding interactions between osteoblasts, osteoclasts, and bone metastatic cancer cells will aid in controlling and ultimately preventing cancer cell metastasis to bone.

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Section: Osteoblasts In the Bone Microenvironment As Contributors mentioning

confidence: 99%

Cancer Metastases to Bone: Concepts, Mechanisms, and Interactions with Bone Osteoblasts

Shupp

Kolb

Mukhopadhyay

et al. 2018

Cancers

114

View full text Add to dashboard Cite

show abstract

“…Despite demonstrated risk factors such as obesity, mechanical abnormality, genetic predisposition, and age, the precise pathogenesis underlying OA remains unclear; which leads to the present therapeutic program for OA is only primarily relieving symptoms not speci c treatment. Several prior OA studies emphasized only synovium [28], articular cartilage [29], and meniscus [30] while ignoring the role of subchondral bone in OA development [31]. Recently, increasing evidence has indicated that the degeneration of articular cartilage was associated with abnormal metabolism of subchondral bone [32,33].…”

Section: Discussionmentioning

confidence: 99%

Identification of Key Genes and Pathways Associated with Differences of Subchondral Bone in Osteoarthritis

Zhang¹,

Yu²,

Zhang³

et al. 2020

Preprint

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BackgroundOsteoarthritis (OA) is a common chronic disease worldwide. Subchondral bone is an important pathological change in OA and responds more rapidly to adverse loading and events compared to cartilage. However, the pathogenic genes and pathways of subchondral bone are largely unclear.ObjectiveThis study aimed to identify signature differences in genes involved in knee lateral tibial (LT) and medial tibial (MT) plateaus of subchondral bone tissue while exploring their potential molecular mechanisms via bioinformatics analysis.MethodsFirst, the gene expression data of GSE51588 was downloaded from the GEO database. Differentially expressed genes (DEGs) between knee LT and MT were identified, and functional enrichment analyses were performed. Then, a protein-protein interactive network was constructed in order to acquire the hub genes, and modules analysis was conducted using STRING and Cytoscape for further analysis. The enriched hub genes were queried in DGIdb database to find suitable drug candidates in OA.ResultsA total of 202 DEGs (112 upregulated genes and 84 downregulated genes) were determined. In the PPI network, ten hub genes were identified. Five significant modules were identified using the MCODE plugin unit. Functional enrichment analysis revealed the most important signaling pathways. Six of the ten hub genes were targetable by a total of 35 drugs, suggesting their possible therapeutic use for OA .ConclusionsThe identified hub genes and functional enrichment pathways were implicated in the development and progression of subchondral bone in OA, thus improving our understanding of OA and offering molecular targets for future therapeutic modalities.

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“…A possible explanation for these discordant effects (effi cacy in early stages and poor response in late stages) is to consider, that the DDD is an active process [11], that progressively affect different essential structures of the vertebral to vertebral joint [4][5][6][7]. The deterioration of these structures is double: However, the ROS produced by the activated macrophages cause the reparatory function of lymphocytes and stem cells to produce many times a transient grade 2 adverse event [10,28,29].…”

Section: Several Clinical Reports and Clinical Trials Have Provedmentioning

confidence: 99%

“…The pathobiology of this condition assumes that an initial acute trauma or degeneration induces a strong infl ammatory response. This infl ammatory response causes the attraction and activation of macrophages in the IVD structures and adjacent bones [9][10][11][12][13]. The concept of this initial infl ammation is to promote healing of damaged tissues [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Ozone therapy with local cellular immune modulation and disc progenitor cell implant is safe, effective and efficient

Grangeat¹,

Ea²,

Erario³

et al. 2020

Open J Orthop Rheumatol

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Do immune cells lead the way in subchondral bone disturbance in osteoarthritis?

Cited by 53 publications

References 151 publications

Cancer Metastases to Bone: Concepts, Mechanisms, and Interactions with Bone Osteoblasts

Cancer Metastases to Bone: Concepts, Mechanisms, and Interactions with Bone Osteoblasts

Identification of Key Genes and Pathways Associated with Differences of Subchondral Bone in Osteoarthritis

Ozone therapy with local cellular immune modulation and disc progenitor cell implant is safe, effective and efficient

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