The current study reports about simple, rapid, sensitive and economic spectrophotometric method for determination of the antihypertensive, Carvedilol (CRV) and the antipsychotic, Aripiprazole (ARP) in pure form and pharmaceutical formulations. The suggested method is based on reaction of the studied drugs with haematoxylin reagent in the presence of boric acid to give a reddish violet chromogen at λmax= 560 nm. The percentage recoveries for the suggested method were 99.78±1.10 and 99.97±1.2 within the concentration ranges of 3-16 μg/mL and 8-32 μg/mL for Carvedilol and Aripiprazole respectively. Results show a minimum detection limit (LOD) of 0.63 and 1.79 μg/mL and a quantification limit (LOQ) of 1.91 and 5.42 μg/mL for Carvedilol and Aripiprazole respectively. The method showed excellent precision, with intra and inter-assay precisions of less than 2.0% at all concentrations. The suggested method was applied successfully for determination of the cited drugs in pure form and pharmaceutical formulations without interference of common pharmaceutical excipients with the method procedure. The suggested method was proved to be valid by analyzing both pure and pharmaceutical formulations, comparing the results obtained with those of the reported methods and demonstrating good accuracy and precision results.