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This work offers for the first time an optimized, highly sensitive, simple, and accurate synchronized spectrofluorimetric technique for the simultaneous measurement of tramadol and celecoxib in powder form, their combined multimodal tablet, and finally spiked human plasma samples. Tramadol and celecoxib were recently released as a new drug combination to alleviate intense, sudden pain when other pain medications had failed. The technique entailed taking measurements of the fluorescence amplitudes of the synchronized spectra at Δλ = 100 nm. Excitation was made at 220 nm

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Sensitive, simple and rapid spectrofluorimetric and spectrophotometric   methods were developed for the determination of Irbesartan (IRB) and Bisoprolol hemifumarate (BPH) in their tablets dosage form. Both methodologies are based on charge transfer reaction between the studied drugs and 7-Chloro-4-nitrobenzen-2-oxa-1, 3-diazole NBD-Cl. The developed orange products were measured in the appropriate solvent fluorometrically at 534 and 538 nm after excitation at 465 and 470 nm for IRB and BPH, respectively. The fluorescence–concentration plots were rectilinear over the range of 2.5–8 μg/mL for IRB and 6–16 μg/mL for BPH with lower detection limits of 0.18 and 0.39 μg/mL and a lower quantification limit of 0.55 and 1.17 μg/mL for IRB and BPH, respectively. The spectrophotometric method is based on measuring the orange colored products which were developed upon charge transfer complex formation between the studied drugs and (NBD-Cl) in organic media. This showed absorption maxima at 476 nm and 479 nm for IRB and BPH, respectively. The absorbance–concentration plots were rectilinear over the range of 20–90 μg/mL for IRB and 40–160 μg/mL for BPH with lower detection limits of 1.37 and 3.98 μg/mL and lower quantification limits of 4.17 and 12.06 μg/mL for IRB and BPH, respectively. Both methods were successfully applied to the analysis of the two selected drugs. The current study showed that the results were in good agreement with the reference methods.

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