Introduction: Limited number of publications describe the influence of tumor growth rate on clinicopathologic features of giant (extreme or gigantic) forms of ameloblastoma (GA). This paper explores the relationship between these two factors. Objectives: To determine the relationship between tumor growth rate of GA and clinico-pathologic factors such as age, gender and histopathologic subtype. Material and methods: GA cases were selected from the published literature based on the criteria described by Kanoi et al., availability of clinical data, such as age and gender of patient, duration of lesion, and three-dimensional size (volume) of specimen after surgical resection. Data collected were used to calculate individual tumor growth rate using modified formula of Merhara et al. Clinico-pathological features and calculated tumor growth rates were compared with other publications. Results: In total, 18 reviewed patients were included into this study, from sixteen publications with 17 patients who fitted the selection criteria and one case of GA from our center. There was gender balance (male : female ratio, 1 : 1), with age ranging 19-73 years (mean, 44.2 ± 15.6 years). Mean age of patients with GA was much higher than in non-GA cases, with statistically significant difference (p = 0.02). There was mild positive correlation (r = 0.219) between surgical volume and duration of tumor, but it was not statistically significant (p = 0.382). Mean specific growth rate was 85% ± 40.1%/year (range, 19.9-170%/year). Comparison of SGR with other clinico-pathological parameters of GA revealed no statistical significance. Conclusions: GA occurred at a higher mean age than other forms, and the mean tumor growth rate was 85% per year. This had no statistical relationship to clinico-pathological characteristics studied.

This study aims to report seven cases of congenital granular cell epulis (CGCE) diagnosed in four teaching hospitals in Southwestern Nigeria over a period of 8 years. CGCE is a rare lesion that presents exclusively at birth. It is benign, but often presents an unsightly appearance, and may be associated with difficulty in feeding, thus early presentation of cases for treatment. The records of the oral and maxillofacial pathology departments of four Nigerian teaching hospitals were assessed for lesions with histological diagnosis of CGCE. Data inclusive of age, gender, anatomic site, and mode of treatment was retrieved and analyzed with SPSS version 21. Seven cases were identified from the four teaching hospitals. All cases occurred in females with an average period of presentation at 7 days after birth. Most of the cases (71.4%) occurred on the maxillary alveolar ridge. Six cases presented as a single pedunculated or sessile lesion, while in one case, three nodules were seen. Although spontaneous regression has been documented in literature, all our cases had surgical excision under local anesthesia without complications or recurrence. All our cases were diagnosed in females and 71.4% were on the maxillary alveolar ridge.

The aim of this study was to report an unusual presentation of mucoepidermoid carcinoma (MEC) on the dorsum of tongue and to add to the body of knowledge on the various sites of occurrence of the lesion. MEC is a malignant, locally invasive tumor of salivary glands composed of varying proportions of mucussecreting and squamous cells, with the presence of intermediate cell differentiation between these other two cell types. More than half of reported cases involve major salivary glands and it is seen rarely on the dorsum of tongue. We present an unusual case of a low-grade MEC on the dorsum of tongue of a 40-year-old man. Discussion on clinical and microscopic types and immunohistochemical features of this tumor is presented in relation to pertinent literature. Biologic behavior and clinical manifestations of MEC usually correlate with its histological grade, which are required for appropriate treatment.