A total of one hundred and twenty eight (128) stool samples were collected from patients attending Ahmadu Bello University Teaching Hospital Zaria and Aminu Kano Teaching Hospital Kano, and screened for the presence of Aeromonas hydrophila infection. Out of the one hundred and twenty eight samples analyzed 4 (3.12%) were found positive for Aeromonas hydrophila infection. Antibioticsusceptibility testing of Aeromonas hydrophila isolated showed that all the 4 (100%) isolates were sensitive to Colistin and Ceftazidime, 3 (75%) to Augmentin and 2(50%) to Gentamicin and Cefuroxine. All the isolates (100%) were however resistant to Cotrimoxazole, Tetracycline, Sulphatriad, Streptomycin, Cephalothin and Ampicilin. This study confirmed that Aeromonas hydrophila as a sole enteropathogen could be responsible for diarrhea and should be considered amongst the causative agents of diarrhea.

The synthesis of new linear monoazaphenothiazine and its substituted derivatives via nickel catalyzed amidation reaction is reported. This was achieved by the condensation of 2-aminothiophenol and 2,3,5-trichloropyridine in aqueous basic medium to produce a new heterocyclic ring, 3-chloro-1-azaphenothiazine. Upon applying, Buchwald-Hartwig Cross coupling reaction, it leads to the syntheses of an array of new 3-amido derivatives which were obtained in good yields. The structures of the synthesized compounds were established based on their analytical and spectra data

The antimicrobial activity of newly synthesized linear monoazaphenothiazine derivatives; 3-benzamido-1-azaphenothiazine, 3-trifluoromethamido-1-azaphenothiazine, 3-trichloromethanamido-1-azaphenothiazine and 3-(4-nitrobenzamido)-1-azaphenothiazine have been evaluated against bacteria and fungal strains. Results showed that most of the linear monoazaphenothiazine derivatives were significantly active against the tested microorganisms. The correlation between antimicrobial activity and the chemical structure of phenothiazines was discussed.