Background: Naringenin is a flavonoid with several different biological effects in central nervous system. As mentioned, naringenin has neuroprotective, memory enhancing, anti-inflammatory and antioxidant effects. Objectives: In this study, we investigated effects of naringenin on pentylenetetrazole and maximal electroshock-induced seizures in mice. Methods: Naringenin was administered at doses of 50, 100 and 200 mg/kg intraperitoneally in two models of seizure. Thirty minutes after different doses of naringenin, phenytoin or diazepam and vehicle, the animal received pentylenetetrazole or current stimulus by an electroconvulsiometer. Results: In maximal electroshock model, naringenin 200 mg/kg reduced the duration of hind limb tonic extension. In pentylenetetrazole seizure model all doses of naringenin increased the latency for convulsion and latency for Straub's tail but only naringenin 200 mg/kg showed significant reduction in duration of myoclonic seizure. Conclusions: According to the results, naringenin showed significant anticonvulsant and neuroprotection activity in two pentylenetetrazole and electroshock models of convulsion in mice and these effects may be mediated by antioxidant properties, agonist activity on GABAA receptors and weakening of glutamate transmission.

Background: Epilepsy is a series of disorders in the central nervous system defined by disruption and abnormality in the electrical activity of the brain. The mechanisms of epilepsy occurrence are not fully determined and the current pharmacological therapeutics have low efficacy and are associated with adverse reactions due to narrow therapeutic indices. Ellagic acid has neuroprotective and antioxidant effects and increases the brain's GABA levels. Objectives: This study was designed to evaluate the effects of ellagic acid on both maximal electroshock and pentylenetetrazole models of acute seizures in mice. Methods: Ellagic acid was administered at the doses of 25, 50, and 100 mg/kg in the two models of seizures. Results: The results showed that ellagic acid was effective at the lowest dose in the maximal electroshock-induced seizure in mice and the duration of hind limb tonic extension (HLTE) was significantly shorter in this group than in the untreated convulsive group. In the pentylenetetrazole convulsion model, ellagic acid significantly increased the latency to convulsion and Straub tail response. The latencies with ellagic acid were longer in groups treated with ellagic acid 25 mg/kg than with ellagic acid 50 and 100 mg/kg. Conclusions: In conclusion, it seems that ellagic acid has anticonvulsant effects in electroshock and pentylenetetrazole models of convulsion but its effects are attenuated or eliminated at higher doses.

Background: Naringenin is a flavonoid with several different biological effects in central nervous system. As mentioned, naringenin has neuroprotective, memory enhancing, anti-inflammatory and antioxidant effects. Objectives: In this study, we investigated effects of naringenin on pentylenetetrazole and maximal electroshock-induced seizures in mice. Methods: Naringenin was administered at doses of 50, 100 and 200 mg/kg intraperitoneally in two models of seizure. Thirty minutes after different doses of naringenin, phenytoin or diazepam and vehicle, the animal received pentylenetetrazole or current stimulus by an electroconvulsiometer. Results: In maximal electroshock model, naringenin 200 mg/kg reduced the duration of hind limb tonic extension. In pentylenetetrazole seizure model all doses of naringenin increased the latency for convulsion and latency for Straub's tail but only naringenin 200 mg/kg showed significant reduction in duration of myoclonic seizure. Conclusions: According to the results, naringenin showed significant anticonvulsant and neuroprotection activity in two pentylenetetrazole and electroshock models of convulsion in mice and these effects may be mediated by antioxidant properties, agonist activity on GABAA receptors and weakening of glutamate transmission.