Castleman disease (Angiofollicular Lymph Node Hyperplasia AFH) is a rare lymphoproliferative disorder that is especially uncommon in the retroperitoneal area. We report a case of 32 year old male who was complaining of shortness of breath and was found to have right sided pleural effusion. Further investigations revealed right sided retroperitoneal mass which was completely excised laparoscopically. Pathologic diagnosis came out as Castleman disease. The patient recovered well after surgery and his shortness of breath and pleural effusion did not recur for the subsequent 6 months of follow up.

Journal of Urology and Nephrology Open Access Open Access Case Report orchiectomy, which microscopically revealed a well differentiated neuroendocrine tumor confined to the testis and epididymis with no lymph vascular invasion. No other teratomatous elements or germ cell components were identified. Immunohistochemistry showed the tumor cells to be positive for chromogranin and CK(MNF) while negative for inhibit, calretinin and melan-A. Ki-67 proliferative index is 3-4% (Figure 1). An extra testicular carcinoid tumor was ruled out and the tumor was staged as pT1NxMx. After two years of follow up with cross sectional imaging and tumor markers including chromogranin A and 5-Hydroxyindoleacetic Acid, no recurrence has been documented and the patient is doing well. Case 2 A 40-year-old male patient, not known to have previous illnesses, who presented with a progressive, painless left testicular swelling, he denied any weight loss, trauma, hematuria or systemic symptoms. On physical examination a hard mass was palpable on the left testis. Upon admission his hemoglobin was 13.6 g/dl, white blood cell count 7.4 10'3/µL, and Creatinine 1.0, electrolytes and liver function test values were within normal range. He had a body mass index of 26 kg/m2.He had ultrasound imaging which showed a mass of about 5cm associated with hydrocele (figure 2,3).