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In the present work, a sensitive optimized electrochemical screen-printed electrode chemically modified with cerium nanoparticles was assigned for the determination of oxymetazoline hydrochloride. The sensing membrane was based on incorporation of ion paring agent i.e. tetraphenylborate associated with the drug as an electroactive material. Asides, paraffin oil was used as a pasting liquid for in this screen-printed electrode whereas cerium nanoparticles, commonly known as nanoceria, were used as oxide ion conductors to increase the electrode surface area and electrical conductivity. Optimization of the experimental parameters was performed using a response surface methodology which enables a graphical clarification of the linkage between different experimental factors and the slope response. The modified sensor with cerium nanoparticles displays a stable and significant linear response with a reproducible potential for five months at Nernstian slope of 59.07 ± 0.76 mV decade−1 over the concentration range (5 × 10−6−1 × 10−2 mol.l−1) at 25 ± oC with a detection limit of 9.72 × 10−7 mol l−1. Furthermore, the proposed approach was successfully used for the analysis of the drug in its pure and dosage form.

Background Pain is a global, complex health problem that includes physical, emotional and social components. The pain management process has many goals, including patient satisfaction, reducing clinical complications, and lowering costs. The physician describes the pain medications in terms of the proven cause and classification of the severity of the pain. The combination of celecoxib and tramadol was recently approved by the FDA in October 2021 for the treatment of acute pain in adults. Objective This paper presents the first published quantitative analytical methods for celecoxib and tramadol. Methods The UV absorption spectra of celecoxib and tramadol showed strong overlap. Mathematical simultaneous equation and ratio difference methods were developed to resolve the spectral overlap and quantify the drugs in the combination mixture. In the simultaneous equation method, the absorbance and absorptivity values at 252 and 217 nm were used to construct two mathematical equations that were used for the simultaneous mathematical quantification of the above drugs. The mathematical manipulation of the ratio difference based on the calculation of the differences in the amplitude values between 250 and 280 nm enabled the quantitative analysis of celecoxib, and the differences in the amplitude values between 221 and 272 nm enabled the quantitative analysis of tramadol. Results The proposed methods were successfully applied to the selective quantitative analysis of celecoxib and tramadol in the synthetic mixtures and in the pharmaceutical tablets without interference of the tablet additives. Conclusion and Highlights The first established simple and validated UV spectrophotometric methods were described for concurrent quantification of the celecoxib and tramadol in their recently approved pharmaceutical formulation.

Two chromatographic techniques were developed and validated for simultaneous determination of the newly co-formulated antidiabetic combination linagliptin and empagliflozin in their pure form and film-coated tables. The first technique was UPLC; the separation and resolution of both analytes were achieved using a Zorbax eclipse plus C 18 column applying an isocratic elution based on phosphate buffer pH 4-acetonitrile (65:35, v/v) as a running mobile phase at flow rate 1.5 ml/min and the effluent was monitored at 220 nm. Augmentation of Lean Six Sigma with UPLC and

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