Background and Objectives: Diabetes mellitus (DM) is a group of metabolic disorders of carbohydrate metabolism in which glucose is underutilized, producing hyperglycemia. Furthermore, it is proposed that the underutilization of glucose is associated with changes in the lipid profile. Changes in lipid profiles are also well related to the severity of DM. This study involved 50 were patients admitted with a diagnosis of DM; blood samples were drawn under aseptic precautions from cases of DM and healthy controls. Necessary investigations were carried out and values were tabulated for cases and controls separately for statistical evaluation. Our Results show that the DM patients compared to controls significant increase in the following parameters were observed. Cholesterol ratios increased. Furthermore, the levels of triacylglycerol increased. We conclude that there is a statistically significant large effect in cholesterol and TG a level of cases compared with controls, cholesterol level is increased and TG levels were well associated with blood sugar also increased .