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Background: It's though that mitochondrial dysfunction is participated in multiple sclerosis (MS) pathogenesis. Serum lactate and uric acid levels are biochemical markers related to mitochondrial dysfunction. Aim of work: to assess mitochondrial dysfunction in sufferers with MS through investigating lactate and uric acid serum levels. Subjects and Methods: This case carried out on 32 patients with MS and 20 safe controls matched by age and sex. Patients have been diagnosed with MS in keeping with McDonald Criteria 2017. Both participants underwent a careful history taking, thorough general and neurological exam and evaluation of serum lactate and uric acid. Using the expanded disability status scale (EDSS), the degree of impairment in sufferers with MS became assessed and fatigue became evaluated the usage of the fatigue severity scale (FSS). Results: Patients had significantly higher serum lactate levels when relative to controls (40.7 ± 18.1 versus 20. 1 ± 5.8 mg/dl, p=0.001). There were no statistically relevant variations among patients and controls regarding serum uric acid levels (4.9± 1.1 versus 5.3 ± 1.2 mg/dl, p=0.337). Correlation analysis showed significantly inverse correlation among levels of serum lactate andEDSS (r=-0.124, p=0.016) and FSS (r=-0.504, p=0.003). Conclusion: Serum lactate but not serum uric acid is elevated in MSpatients. It was associated with EDSS and FSS.

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