Introduction : Typhoid fever is a systemic bacterial illness of public health importance. The disease is transmitted person to person due to fecal contamination of food and water. Aim: Determine the incidence of typhoid disease for patient and caregiver in hospitals of Assuit governorate. Assess the knowledge, attitude of patient and their caregiver about typhoid fever. Methods: Descriptive cross sectional research design used in the present study. The study was carried out in the fever hospitals of Assuit governorate, which consists from (Assuit fever hospital, Dirout fever hospital, Elshamia fever hospital). Sample was total coverage to all cases attended to the previous setting during six months, the total cases around (400) cases (232) patients and (168) caregiver. Tools of the study was assess the knowledge of patient and caregivers about typhoid fever and their attitude reward typhoid disease. Data collection by direct interview to cases and their caregiver started from first January / 2018 to the end June / 2018, data was analyzed by SPSS version 20.0 Results: It was found that satisfactory knowledge of patient and caregiver related to typhoid disease. It was found that negative attitude of patients and caregivers regarding to typhoid disease. Conclusion and Recommendation: It was conclude that all patients and caregivers knowledge satisfactory while negative attitude were observed that toward typhoid fever. The study recommended that education at programs should be organized for patients and caregivers regarding management and prevention of typhoid fever.