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Four series of 1H‐pyrazole derivatives have been synthesized. The first series was prepared by cyclization of the intermediate 3‐(5‐bromo‐2‐thienyl)‐1‐phenyl‐1H‐pyrazole‐4‐carbaldehyde aroylhydrazone 4a—c with acetic anhydride to afford the corresponding oxadiazoline derivatives 5a—c. The other series were prepared by the cyclization of the intermediate 3‐(5‐bromo‐2‐thienyl)‐1‐phenyl‐4‐substituted thiocarbamoylhydrazonomethyl‐1H‐pyrazole 6a—c with acetic anhydride, ethyl bromoacetate or phenacyl bromide giving rise to 3‐(5‐bromo‐2‐thienyl)‐1‐phenyl‐4‐[3‐acetyl‐5‐(N‐substituted acetamido)‐2,3‐dihydro‐1,3,4‐thiadiazol‐2‐yl]‐1H‐pyrazoles 7a—c, 3‐(5‐bromo‐2‐thienyl)‐1‐phenyl‐4‐(3‐substituted‐4‐oxothiazolidin‐2‐ylidenehydrazonomethyl)‐1H‐pyrazoles 8a—c, or 3‐(5‐bromo‐2‐thienyl)‐1‐phenyl‐4‐(3‐substituted‐4‐phenyl‐2,3‐dihydrothiazol‐2‐ylidenehydrazonomethyl)‐1H‐pyra zoles 9a—c respectively. Some of these compounds showed antiinflammatory, antibacterial or antifungal activities comparable to that of Proquazone, Ampicillin, or Clotrimazole respectively.