The aim of this study was to evaluate the effect of oral administration of Alo vera gel 20 % in laboratory rats that exposed to Bisphenol-A at a concentration of (10, 20) mg/kg on its body weight and biological parameters after a period of 28 days. Results showed a significant decrease (P < 0.05) in the bodyweight of groups of rats given Bisphenol A orally. The values of uric acid, creatinine, and urea were significantly increased, there was also a significant increase in the activity of all values of the enzymes ALT, AST, and ALP. Giving an additional quantity of aloe vera gel by drinking water with the presence of Bisphenol A had a significant effect in reducing the negative impact of Bisphenol A on weight, biochemical, and enzymatic parameters.