In women who presented at 28-36 weeks of gestation with TPL, cAGV and FZE can be used as independent predictors of PTB.

Introduction: Ovarian cancer is a relatively common occurrence with the formation of a tumour in the ovaries and is the leading cause of death in the gynecological field. Despite enormous efforts, there are no successful screening methods developed until now to decrease mortality in this regard. Aim: To evaluate nidogen-2 as a new tumour marker combined with higher sensitivity, specificity and accuracy than carbohydrate antigen (CA-125) and Doppler ultrasound to improve early diagnosis of ovarian cancer. Patients and Methods: One hundred and forty-four qualified women with a preliminary diagnosis of adnexal mass were subjected to history, examination, transvaginal Doppler ultrasound and Quantitative assessment of serum level of CA-125 and nidogen-2 followed by the resection of the masses, which were sent for histopathological examination. Results: One-hundred and sixteen cases were benign and 28 cases were malignant. The surgical procedures ranged from limited resection to radical hysterectomy. There was a highly significant correlation between both serum nidogen-2 and CA-125 and the results of histopathological examination (p = 0.0001). Serum nidogen-2 had 91.6% sensitivity, 62% specificity, 37.1% positive predictive value, 97.9% negative predictive value and 68% accuracy (p < 0.05). Conclusion: Nidogen-2 is a new promising ovarian malignancy biomarker that correlates closely with ultrasound and CA125. It did improve the accuracy of diagnosis, but further studies are needed.

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The role of spreader grafts in open rhinoplasty is at times mandatory. Various studies have shown that spreader grafts mot only support nasal function by maintaining the nasal valve support, but also restore nasal dorsum aesthetics and camouflage minor dorsal nasal deviations. This study was aimed to evaluate a surgical modification of the spreader graft to augment the aesthetic and functional outcomes in open rhinoplasty.Patients and Methods: 24 patients (21 females, 3 males), who were candidates for open septo-rhinoplasty, were divided into two groups of 12 each. Group A traditional spreader grafts were applied, while in Group B, the modified diced inverted Y shaped spreader graft was used. Clinical assessments aided with photography were done at 3, 6 and 12 months postoperatively together with CT-scan (6 months), and subjective questionnaires to assess the aesthetic and functional end results. Results:The pre-and post-operative calculations made for the minimal cross sectional area at internal valve level using CT-scan showed there was mild significant changes in Group A more than the Group B (p-values=0.0010). In the Group A, there was an increase in the minimal cross sectional area at the level of the internal valve by more in Group A by +0.023cm 2 , while in Group B it was +0.019cm 2 , respectively.The patient satisfaction of the aesthetic results it was highest (86%) in Group A, but high (57%) in Group B. In addition, the procedure also clinically revealed a significant improvement in nasal obstruction in Group A (71%) and improvement in Group B (43%).Therefore, there was improvement of functional outcomes if spreader graft was used, with more aesthetic improvement if modified spreader graft is used.Conclucion: Modified spreader graft is an applicable, simple technical modification in spreader graft that could improve the aesthetic and functional outcomes in open septorhinoplasty.

Background: the aim of this study was to compare the operative, post-operative, and the oncological short-term outcomes of laparoscopic hysterectomy with lymphadenectomy and open abdominal hysterectomy with lymphadenectomy for early-stage endometrial cancer.Methods: 80 patients with clinical stage I endometrial cancer were enrolled in this trial; they were divided according to their selection of the method of intervention after counselling into two groups: total laparoscopic hysterectomy with pelvic lymphadenectomy group and total abdominal hysterectomy with pelvic lymphadenectomy group.Results: The mean operative time in the TLH group was 140.85± 10.033 minutes and was 118.45±12.713 minutes in the TAH group (p<0.001). The mean blood loss in the TLH group was 127.5±42.9 ml and 220.5± 84.82 ml in TAH group (p<0.001). The mean duration of postoperative ileus was 12.8±5.022 hours in the TLH group, and it was 22.3±5.573 hours in the TAH group (p<0.001). The mean time of hospital stay in the TLH group was 26.7±5.667 hours and in the TAH group was 116.4± 17.31 hours (p<0.001).Conclusions: Complete surgical staging of endometrial cancer can be performed using laparoscopy as an alternative to routine open method with similar efficacy about nodal retrieval and complication rate, and better operative and postoperative compliance in means of blood loss, ileus and hospital stay which may have an implication on cost saving in the medical service. Lymphadenectomy can be omitted in low-risk cases of endometrial cancer.