The purpose of this research article was to examine the impact of conventional Rosmarinus officinalis (without delivery systems) extract and extract incorporated liposomal delivery system on skin permeation velocity in vitro conditions was to determine whether there was a significant difference (in terms of duration) over the determined parameters.The environment condition was 47 mm diameter with a capacity of 20 ml in a water bath applied to the membrane surface in 37 ° C and using a double walled franz diffusion cell containing a syntetic polycarbonate membrane filter. 1., 3., 5., 10., 20., 40. in minutes and upto 160 minutes 50 rpm rotation speed (mimicking the application speed obtained from the skin) with classical methods and delivery named by calculating the transition rates of Rosmarinus officinalis extracts obtained by the alternative method through the diffusion cell.As a result of the study, it was clearly determined that the mixture of Rosemary (Rosmarinus officinalis) extract in the liposomal carrier system at a volume ratio of 1: 1 had an in vitro release rate of around 30% compared to 100% in 40 minutes, respectively, according to the traditional formula.

In late December 2019, the new viral pneumonia outbreak was first detected in Wuhan, the largest metropolitan area in China's Hubei province. The 2019–20 coronavirus pandemic is an ongoing pandemic, caused by the severe acute respiratory syndrome-2 (SARS-CoV-2), was named as Coronavirus disease 2019 (COVID-19) by World Health Organization (WHO). It is well known that radiation can cause mutations in bacteria and viruses. Therefore, characterization of the radiation resistance and interaction properties of viruses provides the opportunity in terms of risk assessment and future aspects. In this study, 3 types of viruses (SARS-CoV-CAS Number 587886-51-9, Influenza-CAS Number 141368-69-6 and SARS-CoV-2 GlycoProtein 6VSB.) were modeled with the Monte Carlo simulation method (MCNPX version 2.6.0). The vital radiation attenuation properties such as linear attenuation coefficients, energy absorption buildup factors (EABF), exposure buildup factors (EBF), relative dose distributions (RDD) were examined using advanced simulation methods. Moreover, the spike protein of SARS-CoV-2 is modelled from the structures in the Protein Data Bank. As a result of the study, we could say that the most radiation resistance was observed in SARS-CoV when compared with Influenza and Covid-19. It could be one of the reasons for SARS-CoV’s resistance to mutation from its outbreak time. On the other hand, Covid-19 is more resistant to radiation than Influenza. Therefore it could be expected that Covid-19 would have the similar behaviors against ionizing radiation as Influenza has.

This research study was designed to investigate physicochemical properties of types of phytosome containing alcohol-free umckalin from Pelargonium sidoides.Fourteen different phytosomal formulations were prepared by film method using P. sidoides in various types of phosphatidylcholine; Phospholipon 85 G (P 85 G) and phospholipon 100H (PL 100H). Physicochemical properties were measured by particle size and size distribution, zeta potential and polydispersity index of optimum 4phytosomal formulation. Polarized light microscopy (PLM) techniques were employed for obtaining size distribution and surface appearance and lamellarity. The determination of vesicle types of phytosomes was performed by using PLM. The most suitable alcohol-free phytosome combination was chosen as PL 100H: DCP: CHOL (10: 1: 4) containing 1 % P.S (UP 4) because of its particle size and distribution (<1000 nm) and zeta potential (<-30 mV).