Background: This cohort study investigated the role of the active matrix metalloproteinase-8 (aMMP-8) and interleukin-6 (IL-6) as oral fluid biomarkers for monitoring the periodontal degeneration occurring in head and neck cancer (HNC) patients treated by radiotherapy. Research design and methods: Eleven patients, aged 28-74, diagnosed with HNC were included in the study. Complete periodontal and oral examinations were performed pre-radiotherapy and 1 month after radiotherapy. Mouthrinse samples (pre-radiotherapy, after 6 weeks of radiotherapy and 1 month after radiotherapy) were assayed by aMMP-8 point-of-care-kit (PerioSafe ® /ORALyzer ® ) for aMMP-8 and ELISA for IL-6.Results: HNC radiotherapy had a deteriorating impact on the periodontium and a significant impact on periodontal biomarkers aMMP-8 and IL-6 and increased their levels in mouthrinse. Clinical-attachment-loss (CAL) (site of greatest loss: mean = 1.7 mm, range = 1-3 mm) corresponding to rapid progression of periodontitis. There was a positive repeated measures correlation (rmcorr = 0.667) between the aMMP-8 and IL-6 levels. Conclusions: Elevated aMMP-8 levels were observed 1 month after radiotherapy among some HNC patients suggesting a prolonged increased susceptibility to further periodontal tissue destruction. Currently available aMMP-8 point-of-care testing could be useful to monitor and assess quantitatively online and real-time the risk of deterioration of periodontal health during HNC radiotherapy.

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ÖZAmaç: Radyasyonlu ortamda çalışan sağlık personelinin radyasyon konusundaki bilincini değerlendirmek için bir anket çalışması yapılmıştır. Ankete Radyoterapi ve Radyoloji bölümlerinde çalışan Teknikerler ile bu bölümde okuyan öğrencilerin katılımı sağlanmıştır. Bu iki grup için elde edilen anket sonuçlarının karşılaştırılması amaçlanmıştır. Materyal ve Metot: Bu çalışma, bölüm, deneyim ve eğitim durumuna göre değerlendirilmiştir. Çalışma verileri değerlendirilirken tanımlayıcı istatistiksel metotların ( frekans, yüzde) yanı sıra verilerin meslek, tecrübe ve eğitim düzeyleri ile karşılaştırılmasında fark bulunup bulunmadığı ki-kare testleri kullanılarak araştırılmıştır. Elde edilen verilerin analizinde SPSS 22.0 programı kullanılmış ve P değerinin 0.05'in altında olduğu durum istatiksel anlamlı sonuçlar olarak değerlendirilmiştir. Bulgular: Anket sonuçlarına göre; Teknikerler, öğrencilerden istatistiksel anlamda daha çok doğru yanıt vermişlerdir. Bu durum aldıkları eğitimin daha kaliteli olması ile açıklanabilir. Bunun yanında, teknikerlerin bilgi düzeylerinin tecrübe ile arttığı ancak temel bilgilerin yerinin doldurulamadığı görülmektedir. Sonuç: Hizmet içi ve hizmet dışı olarak radyasyonlu ortamda çalışan sağlık personelinin radyasyon güvenliği ile bilgilendirmeye ihtiyacı vardır. Bu bilgilerin belli aralıklarla yenilenmesi fayda sağlayacaktır. Ayrıca radyasyon ile çalışan personelin zaman zaman mesleki bilinçlendirme eğitim, seminer ve kongrelere katılarak mesleki bilgilerinin güncellenmesi gerektiği görülmektedir. Anahtar kelimeler: Radyasyon, radyasyon bilinci, radyasyondan korunma, radyoterapi ABSTRACT Objective: A survey study was conducted to evaluate the awareness of the health personnel working in the radiation environment on radiation. The technicians working in the departments of radiotherapy and radiology and the students studying in this department were included in the survey. The aim of this study was to compare the results of the two groups. Materials and Methods:This study was evaluated according to department, experience and educational status. In the evaluation of the study data, whether there is any difference between the descriptive statistical methods (frequency, percentage) and the comparison of data with occupation, experience and education levels, the chi-square tests were used.SPSS 22.0 program was used in the analysis of the data obtained and the value of P value below 0.05 was evaluated as statistically significant results. Results: According to the results of the survey; technicians statistically gave more accurate answers than students. This can be explained by the higher quality of the education they received. Besides, it is seen that the level of knowledge of technicians increased with experience but basic knowledge could not be replaced. Conclusion: Personnel working in radiation environments need to be informed about radiation safety. Periodic renewal of knowledge will be beneficial. Moreover, it is seen that the personnel working with radiation should update their professional ...

aims: It was aimed to determine the amount of radiation dose rate emitted from the patients who underwent imaging with low activity at the new generation PET/CT device. In addition, it was aimed to examine the relationship between biological and physical excretion by measuring the activity amounts in urine and sweat samples with a well-type counter, as well as dose rates measured from various parts of the body with the Geiger Muller counter (GM). This study also aimed to reorganize the clinical conditions by evaluating the dose rates in terms of radiation safety and comparing the results with national and international regulations. background: New generation PET/CT devices provide quality images using low radiopharmaceutical activities. Dose monitoring is carried out for nuclear medicine personnel, other health personnel, and companions by determining the radiation dose emitted from low-activity patients to the environment. In particular, it is necessary to revise the working conditions of the personnel according to the radiation dose exposed. objective: It was aimed to reevaluate the radiation dose rate transmitted to the environment from patients injected with FDG. method: A total of 31 patients (14F, 17M) who underwent 18F-FDG PET/CT imaging were included. The mean 18F-FDG activity of 7.26±1.29 mCi was used for injection. After injection, radiation dose rates (mR/h) were measured at distances of 25, 50, 100, 150, and 200cm for 3 different periods from the level of the head, thorax, abdomen, and pelvis by using a GM counter. Additionally, biological samples such as urine and sweat were taken during 3 different periods. The activity amounts(µCi) in the samples were measured with a well-type counter. result: Strong correlations were calculated between normalized dose rates obtained by all regions and time. Considering the nuclear medicine staff handling time with a PET/CT patient, the average dose received by staff was calculated between a range of 0.002-0.004mSv/pt. The radiation dose exposed to the porter and nurse was calculated as 0.049mSv/pt for the 2nd hour and 0.001-0.007mSv/pt for the 4th hour, respectively. The companion was exposed to a dose between 0.073-0.147mSv and 0.024-0.048mSv for public transport and private car transportation after 4-6 hours of injection (for 30-60 min of travel duration), respectively. For inpatients, the received dose for porters, serving 20min from a distance of 30cm for the 2nd and 4th hours after PET/CT scan, was 0.049 mSv/pt and 0.048 mSv/pt, respectively. And for nurses serving from 50cm distance between 1-5 minutes, these values were found to be 0.001-0.007mSv/pt, 0.001-0.007mSv/pt, and 0.001-0.006mSv/pt, respectively. conclusion: The radiation dose of nuclear medicine staff, porters, nurses, and companions are found to be below the recommended dose limit by the ICRP. According to our results, there is no need for any restrictions for patients, companions, or healthcare personnel in PET/CT units. other: None