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This paper aims to present blasting effects on the structural response of a 5-story building considering its columns, shear walls, beams, slabs, raft foundation, masonry walls, and windows. A building with a geometry of 12×20 m in plan and a height of 15.5 m is considered. The three-dimensional finite element model of the building is constituted using ANSYS Workbench and blasting analysis is explicitly performed in ANSYS AUTODYN. TNT is exploded to give blasting effects on the structure. The duration of the explosion is set to 3-msec. Stresses, displacements, material status, and pressures due to blasting on some gauge points are presented. It is seen from the study that the blast causes local damage to the load-bearing elements.