Analysis of the structure of morbidity and prevalence of congenital malformations among children in the Osh region in 2018-2020. The database was compiled based on the results of the analysis of 950 medical records of children with congenital heart defects (aged 0 to 15 years 11 months) filled in during 2018-2020. Results: the authors have noted an increase in the number of boys and a decrease in the number of girls with congenital heart defects in 2020 compared to 2019 and 2018 (66.4% and 33.6%; 61.3% and 38.7%; 47.3% and 52.7%, respectively). There was a significant decrease (p <0.05) in the number of children aged 0 to 1 year (38.8% in 2020 versus 50.2% in 2018) and a significant (p <0.05) increase in the number of children in the age range 6 to 15 years old (21.1% in 2020 compared to 12.5% in 2018). Significantly more often (p <0.05) in 2018, 2019 and 2020, ventricular septal defect was registered (39.60%; 45.29% and 34.12% of cases, respectively). Conclusion: the study of the peculiarities of the dynamics of registered congenital heart defects among children of the Osh region in 2018-2020 taking into account gender and age characteristics is important for the development of organizational measures for diagnosis and treatment and will make it possible to create a congenital heart defects register in this region, the presence of which will ensure the monitoring of patients with congenital heart defects at every stage from registration to deregistration.

Background: Recently, among child disability disorders nervous system diseases are prevailing 19.5%, while mental disorders are 14.3% and congenital malformations 21%. In most cases, children's neurological disability is associated with pathology during the perinatal period, while 24% of patients have a cerebral impairment. Premature newborns perished 30 to 35 times more often than in-time newborns, and perinatal mortality in case of premature pregnancies is 30 to 40 times higher than in term delivery. Aim: This article is studying catamnestic observation of premature newborns with nervous system injury and with perinatal pathology in Kyrgyzstan for the period 2020-2021. Preterm newborns' anthropometric characteristics and main diagnoses associated with diseases in the gestational period were shown. Methods: A comprehensive clinical and laboratory examination including premature newborns health dynamic monitoring with gestational age from 28 to 36 weeks, who were treated in the neonatal pathology department of the Regional Maternity Hospital in Osh for the period from 2020-2021 were carried out. Literature review analysis from PubMed database, MEDLINE, EMBASE, Science Direct, Google Scholar, and clinical trials performed. Results: after clinical examination, it was revealed that pregnancy and childbirth in all mothers of the studied group passed with complications. In mothers of the studying group, the most common pathologies during pregnancy were chronic fetal hypoxia 49 (58.4%), acute respiratory infections 28 (33.

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