Analysis of the structure of morbidity and prevalence of congenital malformations among children in the Osh region in 2018-2020. The database was compiled based on the results of the analysis of 950 medical records of children with congenital heart defects (aged 0 to 15 years 11 months) filled in during 2018-2020. Results: the authors have noted an increase in the number of boys and a decrease in the number of girls with congenital heart defects in 2020 compared to 2019 and 2018 (66.4% and 33.6%; 61.3% and 38.7%; 47.3% and 52.7%, respectively). There was a significant decrease (p <0.05) in the number of children aged 0 to 1 year (38.8% in 2020 versus 50.2% in 2018) and a significant (p <0.05) increase in the number of children in the age range 6 to 15 years old (21.1% in 2020 compared to 12.5% in 2018). Significantly more often (p <0.05) in 2018, 2019 and 2020, ventricular septal defect was registered (39.60%; 45.29% and 34.12% of cases, respectively). Conclusion: the study of the peculiarities of the dynamics of registered congenital heart defects among children of the Osh region in 2018-2020 taking into account gender and age characteristics is important for the development of organizational measures for diagnosis and treatment and will make it possible to create a congenital heart defects register in this region, the presence of which will ensure the monitoring of patients with congenital heart defects at every stage from registration to deregistration.

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Research relevance: in recent decades, there has been a significant increase in interest in cardiomyopathies, mainly of the heart muscle, often characterized by an unclear etiology, chronic progressive course and, ultimately, cardiomegaly, progressive heart failure, arrhythmic, thromboembolic syndromes, often ending in sudden cardiac death. Materials and research methods: presentation of results after statistical studies on the clinic, diagnostics of a violation of the conducting system by cardiomyopathy in children aged 1 to 16 years, who underwent inpatient treatment in the cardioreumatology department of the Osh medical children’s clinical hospital from 2016 to 2020, according to clinical material on 67 children with dilated cardiomyopathy. Research objectives: analysis of data on 67 children from 0 to 16 years old who received inpatient treatment for heart disease at the Osh interregional children's clinical hospital from 2016 to 2020. Research results: analysis of the EchoCG data of the study showed that the nature of changes in intracardiac hemodynamics depends on the age of the child: the most pronounced shifts in EchoCG indicators, as a rule, are inherent in young children with inflammatory changes in the myocardium and dilated cardiomyopathy, less pronounced for children of other age groups. Conclusions: indicators reflect severe degree of heart damage in children of this age and indicate, most likely, a weak level of heart compensatory-adaptive mechanisms.

A description of two cases of the Takayasu’s arteritis in children, who were under our observation, enrolled in the Department of Cardiology and Rheumatology of the National Center Maternity and Childhood Protection during the pandemic period of the new coronavirus infection in 2021 were presented. The Takayasu’s arteritis should be included in the structure of the differential diagnosis in children and adolescents with clinical manifestations characteristic of post-COVID syndrome.