ABSTRACT Coronary heart disease (CHD) is the leading cause of death after stroke in all age groups at 12.9%. The main reason is the amount of cholesterol in the blood. Tamarind (Tamarindus indica) is a traditional herb that has the potential to lower cholesterol, because it contains flavonoids, saponins, foliphenols, pectin, organic acids, vitamin B and vitamin C that can lower cholesterol. The purpose of this study was to determine the effect of tamarind seed powder (Tamarindus indica) on cholesterol levels. This type of research is experimental with pre-test and post-test with control group research design. The population and sample of this study were a group of mice totaling 32 mice. The location of this research was conducted at the Animal Husbandry Center (PUSVETMA). Data collection procedures were carried out by examining the cholesterol levels of mice before and after treatment. The data obtained were followed up with normality test and independent t test. The results of the study using the unpaired t test gave the result of p=0.000 (p<0.05). The conclusion of this study is that there is an effect of seed powder (Tamarindus indica) on cholesterol levels. Keyword : Seeds Tamarindus indica L., cholesterol levels, Mice (Mus musculus)

Coronavirus Disease (Covid-19) is a new type of virus that has never been  previously identified in humans. Common signs and symptoms of Covid-19 infection include symptoms of acute respiratory distress such as fever, cough and shortness of breath. C-Reactive Protein (CRP) is a protein in serum that causes inflammation in the body. The presence of this inflammatory response causes the levels of CRP in the body to increase significantly. To determine the severity of Covid-19 disease, one of the screening tests used is the CRP examination, starting when clinical symptoms appear, becoming high levels of CRP indicating inflammation or inflammation. This study aims to determine CRP levels in patients who were confirmed positive for Covid-19 at RSU Haji Surabaya. The research method used is descriptive research with secondary data. The sample in the study was 60 patients who had confirmed Covid-19 and performed a CRP test from February to June 2021. The sampling technique used a total sampling technique at the Haji General Hospital Surabaya. The results showed that from 60 confirmed Covid-19 inpatients, 58 patients (96.6%) had CRP levels with high risk criteria or CRP levels > 5 mg/L and 2 patients (3.4%) had CRP levels. with normal criteria or CRP levels < 5 mg/L. Based on the results, it can be concluded that CRP levels are positively correlated with the development and severity of Covid-19 disease.

Oil sludge is a product of petroleum mining activities and causes environmental pollution. However, oil sludge, including hazardous and toxic waste materials (B3), has been less effective in reducing oil sludge pollution. Thus, the researcher solved the issue by using hydrocarbonoclastic. It is necessary to use hydrocarbonoclastic bacteria isolated directly from their habitat (indigenous bacteria) as hydrocarbon degrading agents. Therefore, this study aimed to isolate and identify indigenous thermophilic bacteria from East Kalimantan Oil sludge. This study is an observational study that is analyzed descriptively. Procedure for isolation and identification of thermophilic bacteria from oil sludge grow on Synthetic Mineral Water media (SMW) with and without an autoclave. The Microbact Identification System Kit GNB 24E was used to characterize colonies macroscopically, microscopically, Gram staining, physiological tests (catalase, coagulase, and motility tests), and biochemically. The bacteria that were successfully isolated were later identified with Microbact Software and Bergey's book Manual of Determinative Bacteriology Ninth Edition. The results of the isolation and identification of thermophilic Indigenous bacteria from Oil Sludge Kalimantan Timur found Pseudomonas aeruginosa species with a similarity accuracy of 98.33%. The identified bacterial isolates can later be used as bioremediation agents on soils polluted with oil sludge. Keywords : Indigenous bacteria, Oil Sludge, Pseudomonas aeruginosa.