Considering that in radiation biocenoses in animals under the influence of ionizing radiation, various biological changes occur, in the form of stimulation or suppression of the development of parasites in the host organism, as well as post-radiation changes in the host organism. We have car-ried out these studies, the purpose of which was to determine the infestation of laboratory animals by helminths, to study the effect of parasites on the course of acute radiation sickness and to assess the modifying effect of the «OS» drug on animals with combined radiation-biological damage.

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A two-factor lesion of radiation and burn diseases separately and their combination was modeled. It was found that external γ-irradiation of white rats at a dose of 7.5 Gy causes severe ra-diation sickness with a high mortality rate. At the same time, it was noted that the degree of thermal burn depends on the time of contact with the body surface of a metal plate heated to 190 ° C: its application for 5 seconds causes a III A degree burn, an 8 second exposure - III B degree, as evi-denced by the timing of formation, rejection burn scab and complete healing of thermal injuries. The aggravating effect of ionizing radiation on the course and outcome of combined radiation-thermal pathology was shown. For the treatment of the studied pathology, the drug "OSK" was used, which was applied subcutaneously directly under the burned area of the skin in a dose of 0.4 ml after radi-ation and thermal effects on the body.

As a result of the work carried out, proceeding from the conceptual position of radiation parasitology about a certain commonality of the mechanisms of the pathogenic effect of ionizing radiation and parasitic agents on living organisms, we determined the conditions for modeling para-sitic invasion, as well as combined radiation-helminthic damage to the body using optimal doses of agents of invasive etiology. Irradiation of rabbits at a half-lethal dose of 7.0 Gy, produced before infection with passaluros at a dose of LD50 (1500 eggs of P. ambiguus), aggravates the course of the invasive process and promotes its generalization, accelerating the death of animals. The combined radiation-helminthic lesion proceeds quickly with the absolute death of all affected animals.

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