CardiovasCular adaptations of foreign students to ClimatiC and geographiCal Conditions of stavropol regiona b s t r a c t -Purpose of research: studying adaptive opportunities of the cardiovascular system of foreign students to the climatic and geographical conditions of Stavropol region. Methods: The data sample included the Stavropol and foreign students, natives of the countries of the Southern Asia, the Western Asia and Africa in the youthful period of ontogenesis and the first period of a maturity. In total 218 students, from them the Russian students were examined: youths -73 persons, men -55 people; foreign students: youths -36 people, men -54 persons. Results: Stable and compensatory adaptive reactions are characteristic to youths and men from the Southern Asia and to men from the Western Asia. A condition of the critical tension (excessive tension) are characteristic to firstyear students and senior students from Africa. Findings: It is established that the greatest stress of adaptation mechanisms is experienced by students from Africa. K E y w o r d s -adaptation, mathematical analysis of the heart rhythm, variational pulsometry, foreign students, Stavropol region.

The aim of the research is: to study the morphofunctional characteristics of the peripheral blood cells of healthy young people of the same age group, taking into account the dependence on the ecological and biogeochemical factors of the external environment of the region of residence and to identify the physiological mechanisms underlying adaptation to the external environment. Materials and methods. there were examined 125 students studied at the North Caucasus Federal University at the age of 18–21. For the quantitative evaluation of peripheral blood cells, 15 laboratory parameters were determined on the MEDONIK M-SERIES hematology analyzer. Leukocyte analysis was performed on the MECOS-C3 hardware-software complex. Results. The analysis of peripheral blood indices revealed significant shifts in adaptation processes in the direction of tension in the group of Indian students (P <0.01) and less critical changes in the compensatory-adaptive mechanisms of the body in the group of students from Tajikistan (P <0.05). Conclusion. As a result of the study, new data have been obtained indicating a different spectrum of adaptive reactions of students, which allows the use of peripheral blood as a test system for assessing the influence of damaging environmental factors.

Sepsis is a serious disease accompanied by the development of a systemic inflammatory response syndrome. The informativeness of existing diagnostic markers of sepsis at various stages of its development remains controversial. Research into septic conditions has led to significant progress in determining the body’s response to infection. The search for laboratory indicators capable of indicating the prognosis of the disease is an important diagnostic criterion in the timely treatment and prevention of sepsis in hospital treatment. The publication presents data from a survey of the studied changes in arterial blood parameters in septic patients with a prognostic assessment. The indicators of biomarkers of inflammation in septic patients were analyzed, the tinctorial and other bacteriological properties of pathogens in the development of generalized sepsis were evaluated, the components influencing the favorable and unfavorable outcome of the disease were determined in the research. The identification of laboratory parameters that help to give the real assessment of the severity and prognosis of the disease in patients of the intensive care unit in a timely manner will allow you to choose effective treatment methods, timely adjust the prescribed therapy and reduce the number of deaths.

Patients with the A2 polymorphism of the subunit gene of glycoprotein IIb/IIIa platelet receptors showed an increased level of endothelial dysfunction markers and increased free-radical reactions, as well as an increase in the geometric parameters of platelets, an increase in their functional activity and the appearance of young cells in peripheral blood. A correlation was found between the parameters of platelet hemostasis and the severity of free-radical reactions in women patients with thrombophilia who have A2 polymorphism in the gene of the subunits of the platelet receptor glycoprotein IIb/IIIa. K E Y w o r d s-gene polymorphism, free radical reactions, platelets, thrombophilia.

The work was performed on experimental material. An experimental model of thyrotoxicosis in laboratory animals, white male rats, was obtained by daily administration оf l-thyroxine at a dose of 1.6 mg per 1 kg of body weight. The duration of the experiment was 45 days. 67 mature rats weighing 250–300 g were selected for the experiment. Rats were removed from the experiment after 7, 14, 21, 28, 35 and 45 days. As a control, we used 22 rats that were not injected with L-thyroxine. The level of thyroid hormones in the blood of rats was determined by enzyme immunoassay. A macroscopic study was performed and the size and mass of the rat liver were determined. For histological examination, pieces of liver tissue were taken, and they were fixed in 10 % buffered formalin for 10 days. Histological preparations were prepared by the standard method, using histological, histochemical and immunohistochemical studies. The results of the study showed that in experimental thyrotoxicosis, the level of thyroid hormones increases: T3 (triiodothyronine) equals 21.37 ± 0.03 mmol/l, 4.75 ± 0.02 mmol/l in the control; T4 (thyroxine) equals 2.55 ± 0.03 mmol/l, 1.80 ± 0.03 mmol/l in the control. Macroscopic examination revealed a 2-fold increase in the size and weight of the liver. Histological examination revealed widespread interstitial edema of the liver stroma, dystrophic and destructive changes, necrosis of hepatocytes, formation of cavities, thinning and atrophy of the liver beams, lymphocytic infiltration. The immunohistochemical study shows a decrease in Ki-67 expression level to 1.8 % compared to the control (5.0 %), which indicates a decrease in reparative processes in the liver.