The WHO advises using the Defined Daily Dose (DDD) as a unit of measurement and the Anatomical Therapeutic Chemical (ATC) classification system for tracking and researching drug use. The main objective of the study is to examine changes in drug utilization. Evaluate interventions on prescribing patterns of antibiotics at The Oxford medical college hospital and research Centre. Patient demographics and drug charts are collected using specified case report form for a period of 6 months using random sampling method. Case report form includes patient demographics, laboratory data, diagnosis, and drug chart with frequency, dose, dosage and route of administration. Out of 183 cases analyzes 45.4% were female and 54.7% were male. Most of the cases were in the group of 20 to 31. Average duration of hospitalization in our study population was around 5 days. A total of 299 antimicrobial were prescribed in 183 cases. Cephalosporins were the most preferred antibiotic followed by other antibiotic class. Ceftriaxone was the most common drug among the cephalosporin. Antibiotic prescribing in the hospital is empirical, we would like to recommend that antibiotic selection should be based on the results of cultural and sensitivity testing whenever possible. The percentage of drug prescribed in generic form was found to be less. We recommend larger scope prospective study to emphasize on ensuring of rational use of antibiotics.