COMMUNICATIONS 0 1983 J. Pharm. Pharmacoi.

No abstract

Abstract--Gastroduodenal mucosal damage was endoscopically compared between aceclofenac, a non-steroidal anti-inflammatory drug, and sodium diclofenac of placebo in a double-blind clinical trial. Thirty healthy male volunteers received 150 mg/day of aceclofenac, 75 mg/day of sodium diclofenac or placebo for 2 weeks. Aceclofenac caused significantly less gastropathy than sodium diclofenac, and placebo caused no gastropathy. Both the gastric mucosal hexosamine content and gastroduodenal blood flow were significantly reduced by sodium diclofenac, while gastric mucosal hexosamine was significantly increased and gastroduodenal blood flow was unchanged with aceclofenac. Aceclofenac appears to have a low potential for causing gastroduodenal mucosal damage in humans.

No abstract

The effects of a topical preparation of mycophenolic acid on the experimental allergic contact dermatitis induced by dinitrofluorobenzene was investigated. Visual assessment of skin reactions showed significant efficacy of a topical preparation of mycophenolic acid. This efficacy appeared from the early stage and endured up to 3 days. Morphological changes in the epidermis and dermis layers of animals treated with a mycophenolic acid cream were moderate compared with that in animals treated with vehicle only. In particular, hyperkeratosis was strongly suppressed. Since suppression of inflammatory cell infiltration was also observed, this efficacy might reach to the epidermis and dermis layer.