Two dogs with immune-mediated hemolytic anemia complicated with thromboembolism were presented. Both of the dogs were initially treated with immunosuppressive therapy in conjunction with dalteparin and clopidogrel. Although the immunosuppressive therapy was effective, peritoneal effusion due to thromboembolism was observed during the course of the disease in these dogs. After initiation of rivaroxaban treatment, peritoneal effusion decreased immediately in parallel with the normalization of D-dimer, antithrombin (AT), and thrombin-antithrombin complex (TAT). Hematochezia, cutaneous hemorrhage, and hematuria were observed as adverse events after administration of rivaroxaban in one case. Rivaroxaban was effective for the control of thromboembolism secondary to immune-mediated hemolytic anemia, and D-dimer, AT, and TAT were useful to monitor the status of thromboembolic disease in dogs.

No abstract

Acute lymphoblastic leukaemia should be considered if lymphoblasts are observed in peripheral blood, even if their number is small. The prognosis for cats that have acute lymphoblastic leukaemia is as poor as that for dogs, and further studies are needed to develop effective treatment.

High-capacitance multilayer ceramic capacitors (MLCCs) are mostly electronic ceramic components in which Ni inner electrodes and BaTiO3-based dielectrics are laminated alternately. Owing to their usefulness in portable electronic devices such as smartphones, there is an ongoing demand to attain an MLCC with smaller dimensions and improved capacity. We investigated the effect of alloying Ni inner electrodes with various elements on the leakage current degradation of MLCCs. Fe, Cu, Zn, and Sn were chosen and added to Ni and co-fired with BaTiO3, from which Cu and Sn were alloyed with Ni. The leakage current degradation time of MLCCs using the Ni–Cu and Ni–Sn inner electrodes was longer than that of MLCCs using the Ni internal electrodes. In particular, the leakage current degradation of the MLCCs using Ni–Sn inner electrodes was significantly suppressed. This suppression effect increased as the thickness of the BaTiO3-based dielectrics decreased. This method of optimization of the Ni inner-electrode composition could lead to further miniaturization and increased capacity of MLCCs.