Aim: The aim of this study was to evaluate and investigate changes in HbA1c levels before and after non-surgical periodontal therapy in type-2 diabetes mellitus patients with generalized periodontitis. Materials and Methods: A statistically significant number of type-2 diabetes mellitus subjects diagnosed with chronic generalized periodontitis were included in the study. The selected subjects were randomly allocated to 2 groups. Group 1: Control group: Subjects who received only scaling and root planning. Group 2: Test group: Subjects received antibiotic coverage with non-surgical periodontal therapy (scaling and root planning). Clinical parameters included plaque index, gingival index, PRO MIG pocket depth, and clinical attachment level. In addition, the metabolic parameters were recorded at the same time intervals, which included fasting blood sugar, random blood sugar, and HbA1c levels. Statistical Analysis: ANOVA test was applied to the parameters. Results: HbA1c more significantly reduced by test group compared to the other group. Conclusion: there is definitely a positive effect of nonsurgical on HbA1c levels in type 2 diabetes mellitus. This point levels significantly reduced after conventional non-surgical periodontal therapy. Conclusion: There is definitely a positive effect of non-surgical periodontal therapy on HbA1c levels in type 2 diabetes patients with chronic periodontitis.

Background & objectives: Periodontitis is a destructive inflammatory disease of the supporting tissues of the teeth that occurs in response to a predominantly Gram-negative bacterial infection originating from dental plaque. Periodontitis presents with increased systemic inflammation and is known to contribute to rise in serum lipid levels. The aim of present study was to determine influence of periodontal therapy on serum lipid levels. Methods: A total of 105 consecutive subjects were studied. Group I (n=35) included subjects with chronic generalised periodontitis who were not given periodontal therapy during study period and served as control group. Group II (n=70) comprised of subjects with chronic generalized periodontitis who were rendered needful periodontal therapy. Serum levels of triglycerides, total cholesterol, HDL & LDL cholesterol were measured at day 0 (baseline) and reassessed on day 60. Results: In the treatment group, serum triglycerides (Pre=127.81±59.32 & Post = 121.20 ± 58.94 mg/dL, p < 0.001)), total cholesterol (Pre=176.33±38.31 & Post=171.39±31.19 mg/dL, p=0.045) and mean LDLcholesterol levels (Pre=91.91±28.54 & Post=83.94±26.00 mg/dL, p < 0.001) showed a significant decline from the pre-treatment values. HDL-cholesterol levels did not change significantly in both groups. Other lipid levels were not significantly altered in the control group. Conclusions: Patients of chronic generalised periodontitis who were offered periodontal therapy showed improvement in the various lipid parameters except HDL-cholesterol, which was not significantly altered. Chronic periodontitis in otherwise healthy individuals may therefore, be contributing to the systemic inflammatory burden in these patients and adversely altering the lipid profile.