The novel coronavirus disease has been analyzed as the cause of an outbreak of severe acute respiratory syndrome (SARS-CoV-2) infection with over 312,996 total cases and over 3,983 deaths in Bangladesh as of August 31, 2020. COVID-19 infection showed that a variation number of cases and deaths between the sex differences in immune responses to viruses and gender related risk factors among the male and female, but more severe outcomes in aged men of cases and deaths in 31- 40 and 61-70 years respectively than female. However, the epidemiology of SARS-CoV packages their nucleocapsid phosphoprotein (N proteins) may cross-react with COVID-19in the viral genome into a helical ribonucleocapsid and plays a central role to viral self-assembly and suppressing the RNA interference (RNAi) to overcome the host defense. Hence, most of the Covid-19 infected patients diagnosed and specified with RT-PCR, CT scan, LAMP, NGS, serological tests have become the assessment of the disease. Our mini-review focuses on Sex and gender variations with COVID-19 and their effective management, diagnosis, treatment, and prevention of patients in Bangladesh.