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SUMMARY We have investigated the possibility that the abnormally decreased gall bladder contraction after meals in patients with coeliac disease might result in part from an abnormality in the gall bladder response to endogenous cholecystokinetic hormones -for example, cholecystokinin and motilin -rather than solely from decreased secretion of such hormones. Eight patients with untreated coeliac disease and nine controls received intravenous infusions of the pure synthetic cholecystokinin analogue caerulein, 2-16 ng/kg/hour. Gall bladder emptying was measured on a minute-by-minute basis using ssniTc-HIDA scans. In the patients with coeliac disease, gall bladder emptying was greatly decreased (34.6±9.9 v 615+7±5% at 60 minutes, p

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