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Aiming at the development of novel NO donors, the synthesis and reactivity of the trans- [Ru(bpy)

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The cis-[Ru(bpy) 2 (4-bzpy)(NO)](PF 6 ) 3 complex was prepared (4-bzpy = 4-benzoylpyridine), and characterized by UV-visible, infrared and nuclear magnetic resonance (NMR) spectroscopies and electrochemical techniques. The reaction with cysteine was preliminarily investigated, aiming to shed light on the potential biological mechanism for NO or HNO release mediated by thiols. Furthermore, photochemical behavior of cis-[Ru(bpy) 2 (4-bzpy)(NO)](PF 6 ) 3 was studied, where it was observed NO release upon ultraviolet, blue and green light irradiations. This latter long wavelength showed still good efficiency, which has not been reported for this type of complex. This feature is very important for a potential application in phototherapy. Additionally, vasorelaxant activity was investigated in rat-isolated aorta. This compound exhibited a greater maximum efficacy than sodium nitroprusside (SNP) as a blood vessel relaxant. Nevertheless, the EC 50 for SNP (13.3 nmol L ). Altogether, these results suggest this complex is a promising NO donor agent deserving further biological studies.

This research presents the synthesis and characterization of the photochemical nitric oxide (NO) precursor Ru(salenCO2H)(NO)Cl (I, salenCO2H = N,. This water-soluble ruthenium nitrosyl releases NO upon photolysis with a quantum yield that is pH dependent owing to the nitrosyl to nitrite conversion of that axial ligand at higher pH. Also described are the water, oxygen, and thermal stability of I and the cytotoxicity and the vascular relaxivity properties of I in the dark and under photolysis.