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Desde diciembre del 2019 emergió la infección por coronavirus en el mundo, la cual se declaró pandemia por la Organización Mundial de la Salud (OMS) el 11 de marzo de 2020. Se estableció como epicentro la ciudad de Wuhan, capital de la provincia de Hubei, China (1). Rápidamente se identificó el agente causal de esta enfermedad, un betacoronavirus conocido como síndrome respiratorio agudo severo coronavirus 2 (SARS-CoV-2) (2). Al corte del 05 de junio de 2020, el Centro Europeo para la Prevención y Control de Enfermedades reportaba 6 475 644 casos, con 386 544 decesos en el mundo (3). Para esta misma fecha, en nuestro país se reportaban 35 120 casos y 1087 muertes (4).

Roth spots can occur as ophthalmological manifestations of systemic pathologies that compromise the retinal capillary endothelium. A case report of retinopathy due to hemolytic anemia secondary to Epstein–Barr virus is presented. Given the clinical picture, several differential diagnoses were initially considered causing Roth spots that is why a brief review of the literature is carried out to raise awareness of the diverse pathologies that can be associated with the presence of Roth spots to provide timely referrals.