Introduction and purpose: Cardiovascular disease (CVD) is still the leading cause of death worldwide and causes 49% of mortality in Europe. This makes CVD is the most important reason for premature mortality and Disability Adjusted Life Years (“DALYS”) in that continent. It is associated with variables such as blood pressure, heart rate, circulating catecholamines, markers of blood coagulation and vascular endothelial function which are dependent on different times of the day. The epidemiological data indicate that the biggest number of CVD incidents occur during the early morning hours. In this work we try to discuss the circadian rhythm and its impact on variables which, according to data, are most crucial on CV incident rate. Brief description of the state of knowledge: The cardiovascular disease and mortality risk is associated with variables such as morning blood pressure, fluctuations in metabolism rate or even in immunological response. These variables are dependent on the circadian rhythm. This article covers the most crucial components affected by the daily fluctuations considering the heart according to the literature from the last five years.  Conclusions: This review highlighted the link between circadian rhythm and cardiovascular disease with the purpose of focusing on the most important clinically aspects of that machinery from blood pressure to inflammation. Despite all of these exciting findings which could possibly have future implications in the field of cardiology, there is still a significant need to explore this complicated relationship between the biological clock and the heart.

Introduction : Endometriosis is a disease that currently affects 10-15% of women of reproductive age worldwide. The main problem of female patients, in addition to infertility, is pain, which varies greatly, significantly reduces the quality of life and affects family, social, sexual and professional life. Pharmacological treatment, which is applied both after the excision of the lesions and in patients who were not eligible for surgery, is an important element of pain therapy. There are also other methods, such as appropriate diet change, supplementation, acupuncture, electrotherapy, which are partially effective. Method : review of the recent literature based on PubMEd ,Google scholar research based on the following keywords : endometriosis treatment, hormonal treatment of endometriosis, quality of life of patients with endometriosis Purpose of work : Comparison of the mode of action and effectiveness of individual non-surgical methods of treating pain in patients with endometriosis.

Social media (SM) is now a popular place for content creation and a means of communication between young adults. Their increasing participation in our lives means that they replace us face to face contacts (FTF), which can affect our mental health. The above changes in communication habits may correlate with the occurrence of depressive states and a sense of social isolation. The aim of the study is to analyze the relationship between the use of MS and the occurrence of depressive states in young adults on the basis of selected literature. The topic of emotional support and a sense of social isolation will also be discussed. PubMed and Google Scholar databases were used to select the appropriate literature, and only research was used.  The cited studies on the use of MS and depression showed that people who spent the most time on social media showed an increased risk of experiencing a depressed mood. Another study analyzed the likelihood of depression depending on the method of emotional support. The comparison of emotional support in FTF (face to face) communication with the support obtained through MS showed that the possibility of depressive symptoms was lower for FTF communication and higher for the second method, respectively. The use of social media among young adults contributes to an increased risk of depression, perceived social isolation and reduced emotional support. Moreover, it has been proven that addiction to MS positively correlates with the presence of depressive symptoms.