In this paper, we prove that the Brezis-Nirenberg problem −∆u = |u| p−1 u + ǫuin Ω, u = 0 on ∂Ω,where Ω is a symmetric bounded smooth domain in R N , N ≥ 7 and p = N+2 N−2 , has a solution with the shape of a tower of two bubbles with alternate signs, centered at the center of symmetry of the domain, for all ǫ > 0 sufficiently small. In the case N = 3, a similar result was proved in [9] but only for ǫ ∈ (λ * , λ 1 ) with λ * = λ * (Ω) > 0. Moreover by using a version of the Pohozaev Identity the authors showed that λ * (Ω) = 1 4 λ 1 if Ω is a ball and that no positive solutions exist for ǫ ∈ (0, 1 4 λ 1 ). Note that, by using again Pohozaev Identity, it is easy to check that problem (1.1) has no nontrivial solutions when ǫ ≤ 0 and Ω is star-shaped. Since then, there has been a considerable number of papers on problem (1.1). We briefly recall some of the main ones. Han, in [22], proved that the solution found by Brezis and Nirenberg blows-up at a critical point of the Robin's function as ǫ goes to zero. Conversely, Rey in [30] and in [31] proved that any C 1 − stable critical point of the Robin's function generates a family of positive solutions which blows-up at this point as ǫ goes to zero. After the work of Brezis and Nirenberg, Capozzi, Fortunato and Palmieri [12] showed that for N = 4, ǫ > 0 and ǫ ∈ σ(−∆) (the spectrum of −∆) problem (1.1) has a nontrivial solution. The same holds if N ≥ 5 for all ǫ > 0 (see also [21]).The first multiplicity result was obtained by Cerami, Fortunato and Struwe in [14], in which they proved that the number of nontrivial solutions of (1.1), for N ≥ 3, is bounded below by the number of eigenvalues of (−∆, Ω) belonging to (ǫ, ǫ + S|Ω| −2/N ), where S is the best constant 2010 Mathematics Subject Classification. 35J60 (primary), and 35B33, 35J20 (secondary).