No abstract

Non‐invasive approaches using remotely controllable nanomaterials have demonstrated their potential ability to enhance treatment efficacy in regenerative medicine and tissue repair. Although magnetic nanoparticles (MNPs) have been used for multiple healthcare applications where their remote control properties can show significant advances, enhanced surface functional groups, and electrical properties would expand their capabilities. To address this, in this study, MNPs incorporated Graphene Oxide (GO) based nanocomposites (GOMNPs) are developed and functionalized with TREK1 and Piezo1 antibodies to specifically target the respective mechanosensitive ion channels. Magnetic ion channel activation (MICA) technology is used to remotely activate MG63 osteoblast‐like cells tagged with these functionalized GOMNPs. Remote activation of mechanotransduction pathways shows significant upregulation in osteogenic gene expression as well as enhanced alkaline phosphate activity and calcium mineralization with enhanced bone formation. The development of a GOMNP composite has extensive applicability for future clinical translation.

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Both adsorbing and non-adsorbing surfactant solutions have been investigated by optical reflectivity (OR) on a hydrophilic silica surface over a wide range of solution concentrations. The use of the OR technique is tested at surfactant concentrations well above those usually employed with this approach. To establish a correlation with the OR response expected from these solutions, a simple additive two-part model is introduced comprising an interfacial term and a bulk solution term. The adsorbing system demonstrated the expected regular adsorption isotherm behaviour at lower solution concentrations, and at higher solution concentrations more closely fitted the bulk solution response. When this bulk response was subtracted from the total OR signal, a constant adsorbed amount was found, validating our two-part model approach. Whilst data obtained from alcohol-2 water mixtures also showed the expected non-adsorbing system response with the signal arising exclusively from the bulk solution, other systems (sucrose solutions and non-adsorbing sodium dodecylsulphate) showed more complex behaviour even after the solution refractive index changes had been subtracted. The implications of these data for probing depletion effects for these systems are discussed.