Ensembl (https://www.ensembl.org) has produced high-quality genomic resources for vertebrates and model organisms for more than twenty years. During that time, our resources, services and tools have continually evolved in line with both the publicly available genome data and the downstream research and applications that utilise the Ensembl platform. In recent years we have witnessed a dramatic shift in the genomic landscape. There has been a large increase in the number of high-quality reference genomes through global biodiversity initiatives. In parallel, there have been major advances towards pangenome representations of higher species, where many alternative genome assemblies representing different breeds, cultivars, strains and haplotypes are now available. In order to support these efforts and accelerate downstream research, it is our goal at Ensembl to create high-quality annotations, tools and services for species across the tree of life. Here, we report our resources for popular reference genomes, the dramatic growth of our annotations (including haplotypes from the first human pangenome graphs), updates to the Ensembl Variant Effect Predictor (VEP), interactive protein structure predictions from AlphaFold DB, and the beta release of our new website.

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The devastation in Central America following the 1998 hurricane (Hurricane Mitch) resulted more from economic and political policies than from "natural" disaster. Over the last 30 or 40 years, huge numbers of poor people in these countries have been forced off good, stable agricultural land onto degraded hillsides and into shanty towns constructed on floodplains--areas known to pose serious hazards of flooding and mudslides. This, together with the failure of impoverished countries to anticipate disaster through mass evacuations or to respond effectively to the hurricane's widespread damage--ensured the loss of thousands of lives.

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