This paper aims to explore the entrepreneurship perception among diverse populations in Romania typically seen as vulnerable. It also aims to provide support regarding how the concept might be useful in considering and designing alternative policy interventions. The vulnerable population groups studied in the paper differ by age (seniors), gender (females), income (low income population) and residence (rural community). The paper attempts to answer three research questions: (1) how attitudes towards entrepreneurship differ among vulnerable population groups; (2) how intention of starting a business varies among studied population; and (3) what is the likelihood and desirability of studied population to consider entrepreneurship as a career choice. The data analysed in the paper are extracted from the Amway Global Entrepreneurship Report (AGER) developed for Romania, for the period 2014-2016. Analysis is conducted by taken into consideration the following dimensions of the “entrepreneurship perception”: attitude towards entrepreneurship, intention of starting a business, entrepreneurship as a career choice, and likelihood of self-employment. The paper aims to contribute to advancing research on the less addressed and less understood entrepreneurship perception among vulnerable populations. In the paper we make recommendations for governmental institutions that are meant to contribute to designing policy interventions that will nurture entrepreneurship spirit in Romania.