No abstract

Purpose To assess the ability of a novel imaging device to allow physicians to personalize therapeutic regimens based on objective patient drop administration data. Methods A novel imaging system was used to record video of the drop technique of subjects in clinic (n = 25) or at home (n = 17) for 1 week. Video assessment by a reading center was compared with patient reporting and their prescribed regimen with respect to how many drops were applied and how many landed in the eye. Results Reading center assessment of both drops dispensed and drops landing in the eye was significantly different from the prescribed regimen in the clinic (P d = 0.005, P i o0.001, respectively) and at-home arms (P d = 0.003, P i o0.001, respectively). Conclusions This imaging system is a powerful tool to help physicians tailor patient therapy more accurately, to help researchers evaluate new drop therapies with objective rather than subjective data, and to potentially facilitate better patient training for improved drug delivery.

PURPOSE: To evaluate the effect of enlarging the temporal clear corneal cataract incision on preexisting against-the-rule astigmatism. METHODS: We performed a prospective study of 21 eyes of 21 consecutive patients with astigmatism greater 3*1.75 D, who underwent temporal clear corneal cataract surgery by phacoemulsification. Patients were divided into two groups. The first group, with medium astigmatism, consisted of 14 patients (14 eyes) with 1.75 to 2.74 D of againstthe-rule astigmatism, and had an incision enlarged to 4.5 mm. The second group, with higher astigmatism, consisted of seven patients (seven eyes) with 2.75 to 3.75 D of against-the-rule astigmatism and had an incision enlarged to 5.5 mm. Corneal topography was performed preoperatively and 24 months postoperatively on all eyes. Surgically induced cylinder changes were compared by examining preoperative and postoperative keratometric power using vector analysis. RESULTS: Mean preoperative cylinder in the medium against-the-rule astigmatism group was 2.10 ± 0.23 D and mean postoperative cylinder at 3 months was 1.17 ± 0.29 D. Using vector analysis, mean change in cylinder in the medium group was 0.93 ± 0.42 D (P<001). In the higher against-the-rule astigmatism group, mean preoperative cylinder was 2.85 ± 0.10 D and mean postoperative cylinder at 3 months was 1.63 ± 0.38 D. Mean change in cylinder in the higher astigmatism group was 1.34 ± 0.58 D (P<001). For both groups, Student's f-test showed that the postoperative decrease in cylinder was statistically significant (P=.005). CONCLUSION: By enlarging the size of the standard (2.8 to 3.5 mm) temporal clear corneal cataract incision, pre-existing against-the-rule astigmatism was reduced. [J Refract Surg 2002;18:463-467]

No abstract