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Background and aimSmall intestinal bacterial overgrowth is encountered in bowel disorders, including irritable bowel symptoms. Low degrees of inflammation have been recently reported in the irritable bowel syndrome. We looked for the association between intestinal inflammation and small intestinal bacterial overgrowth in irritable bowel syndrome.MethodsSmall intestinal bacterial overgrowth was assessed by the H2 glucose breath test in 90 consecutive patients with irritable bowel syndrome. A check-up of the oral cavity was carried out before the breath testing. Further on, the patients were classified into two groups, positive and negative, at the breath test. Then they were tested for intestinal inflammation with a fecal test for calprotectin. We used a semiquantitative test for this study. Both groups were compared for the association of intestinal inflammation with small intestinal bacterial overgrowth.ResultsA number of 24/90 (26.7%) patients with irritable bowel syndrome had small intestinal bacterial overgrowth. A positive test for intestinal inflammation was significantly more frequent in patients with irritable bowel syndrome and small intestinal bacterial overgrowth (chi2: p<0.05).ConclusionsSmall intestinal bacterial overgrowth is present in almost one quarter of patients with irritable bowel syndrome. It is significantly associated with intestinal inflammation.

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Introduction. The relationship between gastric microbiota and acid-dependent diseases is currently not fully studied. The study is based on a review of the literature to analyze and reflect the available data on the interaction of gastric microbiota and acid-dependent diseases, as well as brain-gut diseases. Methods. The survey was performed by analyzing data from Medscape, PubMed, Elsevier. The articles  analyzed are in English, Romanian, Russian, published in the last 10 years. Data on the composition (landscape) of the gastric microbiota and their influence on acid-dependent diseases and digestive diseases in general were reflected. Results. The research reflected that in addition to Helicobacter pylori infection, the landscape of the gastric microbiota in the acid stomach (with low pH) is not sterile and includes other types such as: Proteobacteria, Firmicutes, Actinobacteria, Bacteroidetes, Fusobacteria. At the same time, current methods document a bacterial load of 1010-1012 (CFU) / mL in the colon, which is much higher than in the stomach, where it reaches 102-104 CFU / mL. H.pylori influences the diversification of the non-H.pylori gastric microbiota; Decreased diversification increases the risk of carcinogenesis. The aspects of the role of H. pylori in functional dyspepsia, named after the Maastricht Consensus V - H. pylori dyspepsia, were also demonstrated. The taxonomic profiles (Philum-level, Genus-level) of the gastric microbiota require the study of the interrelationships with acid-dependent diseases, as well as the feedback. Conclusions. The study shows that the stomach is not a sterile organ and in addition to H. pylori there are 5 other types of gastric microbiota, which are interrelated with acid-dependent diseases and digestive disorders and vice versa. This issue requires a comprehensive approach