The human gut possesses millions of microbes that define a complex microbial community. The gut microbiota has been characterized as a vital organ forming its multidirectional connecting axis with other organs. This gut microbiota axis is responsible for host-microbe interactions and works by communicating with the neural, endocrinal, humoral, immunological, and metabolic pathways. The human gut microorganisms (mostly non-pathogenic) have symbiotic host relationships and are usually associated with the host’s immunity to defend against pathogenic invasion. The dysbiosis of the gut microbiota is therefore linked to various human diseases, such as anxiety, depression, hypertension, cardiovascular diseases, obesity, diabetes, inflammatory bowel disease, and cancer. The mechanism leading to the disease development has a crucial correlation with gut microbiota, metabolic products, and host immune response in humans. The understanding of mechanisms over gut microbiota exerts its positive or harmful impacts remains largely undefined. However, many recent clinical studies conducted worldwide are demonstrating the relation of specific microbial species and eubiosis in health and disease. A comprehensive understanding of gut microbiota interactions, its role in health and disease, and recent updates on the subject are the striking topics of the current review. We have also addressed the daunting challenges that must be brought under control to maintain health and treat diseases.

Healthy diets have been demonstrated to complement benefits of physical activity, physical condition and mental wellbeing, all of them being important factors influencing the quality of life of elderly. Unfortunately malnutrition is a serious threat and an increasingly prevalent condition among the fast-growing elderly population. The present work addresses the identification of important factors contributing to decreased appetite and food intake as well as the development of approaches towards a healthy diet and personalised nutrition in elderly. Within the present study semi-structured interviews with elderly and elderly suffering from swallowing and mastication difficulties have been performed, results being used for the development of food provision modules and the corresponding recipes addressing the nutritional requirements of elderly. The social context and the swallowing and mastication difficulties influence the eating behaviour as well as the motivation to eat. On the other hand, it was found that texture modified foods (food which texture is adapted to the need of people with swallowing and mastication problems) could act as motivational aspect. With regard to food personalisation in the elderly the consideration of three different case scenarios based on individual independency and the degree of oral impairment seemed to be appropriate. Different aspects such as gender weight, physical activity level as well as high protein demand are important influential factors in the development of personalised recipes in elderly. In addition to the above, a conversational agent was developed as behaviour change module and can be successfully used as smart personal assistant in helping the users to understand their eating habits and adopt healthier nutrition over the long term.

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The aim of this study was to encapsulate the oleoresins rich in carotenoids extracted from sea buckthorn (Hippophae rhamnoides) fruits into a blend of sodium-alginate and κ-carrageenan microbeads (2% w/v) coated by a sodium-alginate (2% w/v) layer prepared using an ionotropic gelation technique with calcium chloride (2% w/v) by dropping method. The fresh obtained coated microbeads had a “fried eggs” like appearance with a size distribution ranging from 4 to 6 mm. The coated microbeads were analyzed for their SEM and fluorescence. The encapsulation efficiency was 92%. Their stability was investigated by evaluation of the physical integrity performance in aqueous media with different pH to mimic the gastrointestinal tract for 24 h at 37 °C under laboratory conditions. The results demonstrated the limitation of the coated microbeads swelling ability under pH 7. The coated microbeads could be a good tool to guarantee oleoresins rich in carotenoids stability and colon delivery. The present study shows an attractive encapsulation system of oleoresins, in order to obtain stable products for further applications.

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