The present study was carried out to evaluate the in alloxan (150 mg/kgb.wt) induced diabetic rats. The ethanolic extract of Durian (Durio zibethinus Murr.) and rambutan (Nephelium lappaceum L.) fruit peels administered orally to the diabetic rats for 11 days, produced significant decrease in the level of blood glucose. The highest percentage reduction in blood glucose levels were shown of rambutan fruit peels extract with dose 500 mg/kgb.w and the value of persentage reduction were 61.76±4.26%.