Many researches have focused on the health and therapeutics properties and behaviour of phytochemical products, that including bee products. Bee pollen comprises on very large compounds such as flavonoids, phenolic acids and terpenoids, which have inhibiting effect on some enzymes. Monoamine oxidase (MAO) was an important metabolic enzyme. The aims of this study was to evaluation the effects of aqueous and ethanolic extracts of bee pollen on MAO and activities in human sera. The identification of extracts constituents was carried out by GC-Ms analysis technique. The results of the present study manifested the effectiveness of these two extracts which have an inhibitory effects on MAO. Different extracts and volumes have been used in this study which shows the inhibition percentage at maximum level equal to (79, 57) % in MAO and (57.33) % in ethanolic and aqueous extracts respectively. The recorded Km values in ethanolic extract were higher than Km in the aqueous extract, whereas the recorded Vmax values in aqueous extract were higher than Vmax in ethanolic extract. On the other hand, GC-Ms analysis of bee pollen extracts revealed the existence of 40 compounds.