Background: Living successfully with diabetes mellitus requires the very large task of managing a serious chronic condition. The tasks associated with diabetes can be complex and demanding and most people in their life journey with diabetes report great frustration with the burden of the disease. Aim: Study of the effect of Glycemic Control on the Diabetes-Related Distress in a sample of Egyptian patients with Diabetes mellitus. Patients and methods: this a cross sectional study conducted on 350 patients with T2DM attending the outpatient clinic of endocrinology of El Agouza Police Hospital.Fasting blood glucose, Post prandial blood glucose, HbA1c, hs-CRP, Creatinine, BUN, SGPT and SGPT were assessed, BMI, Waist /Hip Ratio, also Diabetes Distress Screening Scale Questionnaire was completed by the patients.Results: There is a statistically significant positive relationship between HbA1c and Total DDS score, Emotional burden, Physician related distress, Regimen related distress, and Interpersonal distress with P-value 0.000, 0.000, 0.000, 0.032, and 0.001 respectively. Conclusion:Diabetes related Distress is associated with poor glycemic control and also inflammation.

We investigated clinical implications of serum tenascin-C (TN-C) levels in patients with acute myocardial infarction (AMI) treated with thrombolytic therapy Serum TN-C levels were measured by ELISA in 60 cases presented with acute STEMI and 20 normal controls. The mean serum TN-C level of AMI patients on admission (57.5 ng/ml) was significantly higher than that of controls (57.49 ± 19.89 ng/ml vs. 34 ± 3.02 ng/ml; p=0.0001), follow-up examination (mean: 6 months) revealed that 17 of 60 AMI (28%) patients showed left ventricular (LV) remodeling (20% enddiastolic volume increase), and in 6 (10%), major adverse cardiac events (MACE) were detected. By receiveroperating characteristic (ROC) analysis, TN-C levels clearly discriminated prediction of LV remodeling and MACE compared with other variables including creatine kinase-MB, and LV function. Diabetes and TN-C were correlated with MACE in our study. The findings suggest that serum TN-C levels might be useful in predicting LV remodeling and prognosis after AMI.